Correlations Between Trabecular Bone Score, Measured Using Anteroposterior Dual-Energy X-Ray Absorptiometry Acquisition, and 3-Dimensional Parameters of Bone Microarchitecture: An Experimental Study on Human Cadaver Vertebrae
Correlations Between Trabecular Bone Score, Measured Using Anteroposterior Dual-Energy X-Ray Absorptiometry Acquisition, and 3-Dimensional Parameters of Bone Microarchitecture: An Experimental Study on Human Cadaver Vertebrae
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DOI：
10.1016/j.jocd.2011.05.005
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发表时间：
2011-07-01
影响因子：
2.5
通讯作者：
Krieg, Marc-Antoine
中科院分区：
文献类型：
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作者：
Hans, Didier;Barthe, Nicole;Krieg, Marc-Antoine
开发一种新的技术，有效的，非侵入性的骨微结构的临床评价仍然是至关重要的和具有挑战性的。骨小梁评分（TBS）是一种新的灰度纹理测量方法，适用于双能X射线吸收法（DXA）图像。TBS和标准的三维（3D）骨微结构参数之间的显着相关性已获得使用数值模拟方法。本研究的主要目的是经验性地评估这种相关性的前后脊柱DXA图像。对30个干燥的人尸体椎骨进行了评价。骨块的微计算机断层扫描采集以93 inN的各向同性分辨率获得。在椎体内确定的区域（不包括皮质骨）评价骨微结构的标准参数。在Prodigy DXA系统（GE Medical-Lunar，麦迪逊，WI）上使用定制的定位装置和实验装置测量骨块。TBS和骨微结构的3D参数之间检测到显着的相关性，大多独立的TBS和骨密度（BMD）之间的任何相关性。TBS和连接密度之间的相关性最大，TBS解释了大约67.2%的方差。基于多元线性回归模型，我们已经建立了一个模型，允许TBS和三维骨微结构参数之间的关系的解释。该模型表明TBS在具有相似BMD但不同骨微结构的样品之间增加了更大的区分价值和能力。它已被证明，它是可能的，以估计骨微结构状态来自DXA成像使用TBS。
Developing a novel technique for the efficient, noninvasive clinical evaluation of bone microarchitecture remains both crucial and challenging. The trabecular bone score (TBS) is a new gray-level texture measurement that is applicable to dual-energy X-ray absorptiometry (DXA) images. Significant correlations between TBS and standard 3-dimensional (3D) parameters of bone microarchitecture have been obtained using a numerical simulation approach. The main objective of this study was to empirically evaluate such correlations in anteroposterior spine DXA images. Thirty dried human cadaver vertebrae were evaluated. Micro-computed tomography acquisitions of the bone pieces were obtained at an isotropic resolution of 93 inn. Standard parameters of bone microarchitecture were evaluated in a defined region within the vertebral body, excluding cortical bone. The bone pieces were measured on a Prodigy DXA system (GE Medical-Lunar, Madison, WI), using a custom-made positioning device and experimental setup. Significant correlations were detected between TBS and 3D parameters of bone microarchitecture, mostly independent of any correlation between TBS and bone mineral density (BMD). The greatest correlation was between TBS and connectivity density, with TBS explaining roughly 67.2% of the variance. Based on multivariate linear regression modeling, we have established a model to allow for the interpretation of the relationship between TBS and 3D bone microarchitecture parameters. This model indicates that TBS adds greater value and power of differentiation between samples with similar BMDs but different bone microarchitectures. It has been shown that it is possible to estimate bone microarchitecture status derived from DXA imaging using TBS.