Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study
Longitudinal Associations of Exposure to Perfluoroalkylated Substances in Childhood and Adolescence and Indicators of Adiposity and Glucose Metabolism 6 and 12 Years Later: The European Youth Heart Study
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DOI：
10.2337/dc16-0269
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发表时间：
2016-10-01
期刊：
影响因子：
16.2
通讯作者：
Jensen, Tina K.
中科院分区：
文献类型：
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作者：
Domazet, Sidsel L.;Grontved, Anders;Jensen, Tina K.
目的探讨儿童（9岁）和青少年（15岁）接触全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）等全氟烷基化物质与青少年（15岁）和青年（21岁）肥胖和葡萄糖代谢指标的长期关系。其次，我们的目标是阐明从童年到青年成年的暴露跟踪程度。研究设计和方法数据来源于一项大型多中心前瞻性队列研究，在该研究中，相同的参与者从童年（N = 590）、青春期（N = 444）到青年期（N = 369）进行了观察。对储存的血浆样品进行全氟辛烷磺酸和全氟辛酸分析。肥胖指标包括身高、体重、四个皮肤褶皱的总和和腰围，以及葡萄糖代谢指标包括空腹血糖、甘油三酯和胰岛素水平、β细胞功能和胰岛素抵抗，这些指标在所有研究阶段都已收集。在控制基线结果水平、性别、年龄和社会经济因素的同时，应用多元线性回归对早期暴露对后期结果的影响进行建模。结果儿童时期暴露于全氟辛烷磺酸与15岁时的肥胖指标相关，表现为BMI、皮褶厚度和腰围升高，以及21岁时皮褶厚度和腰围增加。儿童时期接触PFOA与15岁时b细胞功能下降有关。我们没有观察到青春期暴露与成年早期肥胖和葡萄糖代谢指标之间的联系。结论：本研究发现儿童暴露于全氟辛烷磺酸和全氟辛烷磺酸可分别预测15岁和21岁时的肥胖和15岁时的b细胞功能受损。
OBJECTIVETo investigate the long-term association of exposure to perfluoroalkylated substances, including perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), during childhood (9 years) and adolescence (15 years) on indicators of adiposity and glucose metabolism in adolescence (15 years) and young adulthood (21 years). Secondarily, we aim to clarify the degree of tracking of exposure from childhood into young adulthood.RESEARCH DESIGN AND METHODSData derived from a large multicenter prospective cohort study, in which the same participants have been observed from childhood (N = 590), during adolescence (N = 444), and into young adulthood (N = 369). Stored plasma samples were analyzed for PFOS and PFOA. Indicators of adiposity comprising body height, body weight, sum of four skinfolds, and waist circumference, as well as indicators of glucose metabolism, comprising fasting blood glucose, triglyceride, and insulin levels, beta-cell function, and insulin resistance, have been collected at all study waves. Multiple linear regression was applied in order to model earlier exposure on later outcome while controlling for baseline outcome levels, sex, age, and socioeconomic factors.RESULTSChildhood exposure to PFOS was associated with indicators of adiposity at 15 years of age that are displayed in elevated BMI, skinfold thickness, and waist circumference, as well as increased skinfold thickness and waist circumference at 21 years of age. PFOA exposure in childhood was associated with decreased b-cell function at 15 years of age. We did not observe associations between exposure during adolescence and indicators of adiposity and glucose metabolism in young adulthood.CONCLUSIONSThis study found evidence for childhood exposure to PFOS and PFOA predicting adiposity at 15 and 21 years of age and impaired b-cell function at 15 years of age, respectively.