Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis.
Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio predict length of hospital stay in myocarditis.
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DOI：
10.1038/s41598-021-97678-6
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发表时间：
2021-09-13
影响因子：
4.6
通讯作者：
Lichtenauer M
中科院分区：
文献类型：
--
作者：
Mirna M;Schmutzler L;Topf A;Hoppe UC;Lichtenauer M
中性粒细胞与淋巴细胞比率（NLR）和单核细胞与淋巴细胞比率（MLR）与各种疾病的严重程度相关。本研究的目的是证明NLR和MLR与心肌炎严重程度的关系。本研究回顾性纳入了202例连续心肌炎患者。实验室参数和临床数据从医院记录和出院信中提取。中位NLR为2.48（IQR 1.55-4.58），中位MLR为0.42（IQR 0.39-0.58）。NLR和MLR与HF、CRP和白细胞计数相关，MLR进一步与LV收缩功能呈负相关（rs =-0.379，p = 0.030）。与CRP、白细胞计数、IL-6或降钙素原相比，两个比值与住院时间的相关性更好（NLR：rs = 0.435，p = 0.003; MLR：rs = 0.534，p < 0.0001）。计算用于预测住院时间延长的AUC（NLR = 0.75，MLR = 0.80）和最佳临界值。发生院内并发症的患者显示出更高的NLR，但是，这仍然没有统计学意义。NLR和MLR与心肌炎患者的住院时间以及几个临床和实验室参数相关。由于白色血细胞分类相对容易且快速，因此这两个比率可以促进受影响患者的进一步风险分层。
Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are associated with the severity of various diseases. The aim of this study was to demonstrate the relationship of NLR and MLR with the severity of myocarditis. 202 consecutive patients with myocarditis were retrospectively enrolled in this study. Laboratory parameters and clinical data were extracted from hospital records and discharge letters. Median NLR was 2.48 (IQR 1.55–4.58) and median MLR was 0.42 (IQR 0.39–0.58). NLR and MLR correlated with HF, CRP and leukocyte count, MLR further correlated inversely with LV systolic function (rs = − 0.379, p = 0.030). Both ratios correlated better with length of hospital stay (NLR: rs = 0.435, p = 0.003; MLR: rs = 0.534, p < 0.0001) than CRP, leukocyte count, IL-6 or procalcitonin. AUCs for the prediction of prolonged hospital stay (NLR = 0.75, MLR = 0.80), and optimal cut-offs therefor were calculated. Patients who had in-hospital complications showed a higher NLR, however, this remained statistically insignificant. NLR and MLR correlated with the length of stay, as well as with several clinical and laboratory parameters in patients with myocarditis. Since white blood cell differentials are relatively easy and fast to perform, both ratios could facilitate further risk stratification in affected patients.
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影响因子：
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