THE EFFECTS OF H-2 AND NON-H-2 GENES ON THE EXPULSION OF THE NEMATODE TRICHURIS-MURIS FROM INBRED AND CONGENIC MICE
THE EFFECTS OF H-2 AND NON-H-2 GENES ON THE EXPULSION OF THE NEMATODE TRICHURIS-MURIS FROM INBRED AND CONGENIC MICE
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DOI：
10.1017/s0031182000080173
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发表时间：
1988-06-01
期刊：
影响因子：
2.4
通讯作者：
WAKELIN, D
中科院分区：
文献类型：
--
作者：
ELSE, K;WAKELIN, D
比较了两组H-2同源品系小鼠对小鼠鞭虫线虫初次感染的敏感性。BALB遗传背景的小鼠比B10遗传背景的小鼠明显更耐药，如T.大肠中的小鼠。在具有H-2k单倍型的两组H-2同源品系小鼠（BALB/k，B10. BR）比表达其他单倍型的小鼠更易感染;表达H-2b（B10）或H-2 q（B10.G）等位基因的B10背景菌株是所研究的四种同源菌株中最耐药的。在四个B10同源株中的三个内观察到差异性抗性，这在保护性免疫应答与蠕虫发育的发展速率方面进行了讨论。这些结果支持了H-2连锁和非H-2基因在控制将蠕虫从肠道排出的免疫反应中起重要作用的结论。
Two groups of H-2 congenic strains of mice were compared for their susceptibility to a primary infection with the nematode Trichuris muris. Mice of the BALB genetic background were markedly more resistant than mice of the B10 genetic background, as reflected by the rate of expulsion of T. muris from the large intestine. Within each of the two groups of H-2 congenic strains mice possessing the H-2k haplotype (BALB/k, B10. BR) were more susceptible to infection than mice expressing other haplotypes; B10 background strains expressing H-2b (B10) or H-2q (B10.G) alleles were the most resistant of the four congenic strains studied. Differential resistance was observed within three of the four B10 congenic strains and this is discussed in terms of rate of development of the protective immune response in relation to worm development. The results support the conclusion that both H-2-linked and non-H-2 genes play important roles in controlling the immune response which expels worms from the gut.