Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis.

Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis.
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肿瘤血管生成动态对比增强超声成像的最新进展。

DOI:
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发表时间:
2014
期刊:
Imaging in Medicine
影响因子:
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通讯作者:
K. Hoyt
K. Hoyt
中科院分区:
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文献类型:
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作者:
Reshu Saini;K. Hoyt

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血管生成是肿瘤生长和转移扩散的关键过程。人们对开发用于成像肿瘤血管生成的非侵入性方法非常感兴趣,超声(US)是应对这一挑战的新兴平台技术。血管内微泡造影剂的引入不仅允许在US检查期间实时可视化肿瘤灌注,而且它们可以用特定配体功能化以允许在肿瘤内皮上过表达的血管生成生物标志物的分子US成像。本文就肿瘤血管生成超声成像的概念、发展趋势及相关的临床前和临床研究进展作一综述。
Angiogenesis is a critical process for tumor growth and metastatic dissemination. There is tremendous interest in the development of noninvasive methods for imaging tumor angiogenesis, and ultrasound (US) is an emerging platform technology to address this challenge. The introduction of intravascular microbubble contrast agents not only allows real-time visualization of tumor perfusion during an US examination, but they can be functionalized with specific ligands to permit molecular US imaging of angiogenic biomarkers that are overexpressed on the tumor endothelium. In this article, we will review current concepts and developing trends for US imaging of tumor angiogenesis, including relevant preclinical and clinicsal findings.
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