Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior.
Layer 5 Circuits in V1 Differentially Control Visuomotor Behavior.
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V1 中的第 5 层电路差异化地控制视觉运动行为。
DOI：
10.1016/j.neuron.2019.10.014
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发表时间：
2020
期刊：
影响因子：
16.2
通讯作者：
Higley,MichaelJ
中科院分区：
文献类型：
--
作者：
Tang,Lan;Higley,MichaelJ
新皮质感觉区被认为是分配中心，将有关外部环境的信息传输到下游区域。在初级视觉皮质内，不同群体的锥体神经元(PNS)向不同的目标发送轴突投射，这表明多个细胞网络可能在行为过程中独立参与。我们通过训练小鼠进行一种新的眨眼条件反射任务，研究了PN亚群是否支持视觉检测。应用双光子钙成像和对解剖定义的三叉神经核的光遗传操作，我们发现第五层桥脑皮质神经元强烈编码感觉和运动任务信息，并且选择性地是执行任务所必需的。我们的发现支持一种模型，在该模型中，目标特定的皮质子网络通过将相关信息引导到不同的大脑区域，形成适应行为的基础。总体而言，这项工作突出了神经元形成物理上分散但功能分离的网络的潜力，这些网络能够并行、独立地控制感知和行为。
Neocortical sensory areas are thought to act as distribution hubs, transmitting information about the external environment to downstream areas. Within primary visual cortex, various populations of pyramidal neurons (PNs) send axonal projections to distinct targets, suggesting multiple cellular networks may be independently engaged during behavior. We investigated whether PN subpopulations differentially support visual detection by training mice on a novel eyeblink conditioning task. Applying 2-photon calcium imaging and optogenetic manipulation of anatomically defined PNs, we show that layer 5 corticopontine neurons strongly encode sensory and motor task information and are selectively necessary for performance. Our findings support a model in which target-specific cortical subnetworks form the basis for adaptive behavior by directing relevant information to distinct brain areas. Overall, this work highlights the potential for neurons to form physically interspersed but functionally segregated networks capable of parallel, independent control of perception and behavior.