Neuropsychological, Neuropsychiatric, and Clinical Correlates of Affective and Cognitive Theory of Mind in Parkinson's Disease: A Meta-Analysis
Neuropsychological, Neuropsychiatric, and Clinical Correlates of Affective and Cognitive Theory of Mind in Parkinson's Disease: A Meta-Analysis
复制标题
DOI：
10.1037/neu0000807
复制
发表时间：
2022-04-07
期刊：
影响因子：
2.4
通讯作者：
Santangelo，Gabriella
中科院分区：
文献类型：
--
作者：
Maggi，Gianpaolo;Cima Munoz，Amable Manuel;Santangelo，Gabriella
客观心理理论 (ToM) 是推断他人精神（认知）和情感（情感）状态的能力，这两种状态在帕金森病 (PD) 中都会受到损害。然而，PD 情感和认知 ToM 缺陷背后的临床、神经心理学和神经精神学特征尚不清楚。因此，我们进行了一项荟萃分析研究，以测试 PD 人口统计学、临床、神经心理学或神经精神学变化是否与这两个 ToM 过程存在不同的相关性。方法截至 2022 年 1 月进行了系统文献检索，包括按照我们的检索词进行的总共 31 项研究。每项研究的数据均来自人口统计学（年龄、教育程度）、临床（疾病持续时间、Hoehn & Yahr 分期系统、统一帕金森病评定量表 III、左旋多巴每日等效剂量）、神经心理学（整体认知功能、记忆子域、执行功能子域、处理速度/复杂注意力/工作记忆、视觉空间和构建能力以及语言）和神经精神学（抑郁、冷漠、焦虑）结果 PD 中的情感 ToM 损伤与较低的教育水平和整体认知、生成能力、决策能力、注意力/工作记忆和语言缺陷有关。相反，认知 ToM 缺陷与高龄、整体认知能力较差、执行功能障碍和语言障碍有关。药物调节了注意力/工作记忆与认知思维之间的关系，而年龄调节了情感思维与语言之间的关系。 ToM 缺陷与患者的神经精神或临床状态之间没有发现显着关联。结论这些发现阐明了解释 PD 中 ToM 缺陷的神经心理学和临床特征。我们的结果可能表明需要探索PD社会认知变化背后涉及额纹状体和颞顶叶回路的复杂神经网络。（PsycInfo数据库记录（c）2022 APA，保留所有权利）
ObjectiveTheory of mind (ToM) is the ability to infer others’ mental (Cognitive) and emotional (Affective) states, both being impaired in Parkinson’s disease (PD). However, the clinical, neuropsychological, and neuropsychiatric features underlying Affective and Cognitive ToM deficits in PD are unclear. Therefore, we performed a meta-analytic study to test whether PD demographical, clinical, neuropsychological, or neuropsychiatric changes related differently to both ToM processes.MethodA systematic literature search was performed up to January 2022, including a total of 31 studies following our search terms. Data from each study were obtained from demographic (age, education), clinical (disease duration, Hoehn & Yahr staging system, Unified Parkinson’s Disease Rating Scale-III, levodopa equivalent daily dose), neuropsychological (global cognitive functioning, memory subdomains, executive functions subdomains, processing speed/complex attention/working memory, visuospatial and constructional abilities, and language), and neuropsychiatric (depression, apathy, anxiety) variables.ResultsAffective ToM impairment in PD was related to lower educational level and global cognition, deficits of generativity, decision making, attention/working memory, and language. Conversely, Cognitive ToM deficits were associated with advanced age, poorer global cognition, executive dysfunctions, and language impairments. Medication moderated the relationship between attention/working memory and Cognitive ToM, whereas age moderated the association of Affective ToM with language. No significant associations were found between ToM deficits and patients’ neuropsychiatric or clinical states.ConclusionsThese findings clarify the neuropsychological and clinical features that explain ToM deficits in PD. Possibly, our results suggest the need to explore the complex neural networks involving frontostriatal and temporoparietal circuits behind changes in social cognition in PD.(PsycInfo Database Record (c) 2022 APA, all rights reserved)