The evolution of synthetic oral drug properties
The evolution of synthetic oral drug properties
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DOI：
10.1016/j.bmcl.2004.12.024
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发表时间：
2005-02-15
影响因子：
2.7
通讯作者：
Proudfoot, JR
中科院分区：
文献类型：
--
作者：
Proudfoot, JR
An analysis of the properties of 1791 synthetic, oral drugs approved and/or marketed since 1937 demonstrates that the median molecular weight of oral drugs has increased substantially over the past 60 years. Fewer than 5% of approved/marketed oral drugs have more than 4-H bond donors and just 2% have MW > 500 and >3 H-bond donors. (C) 2004 Elsevier Ltd. All rights reserved.
