Candida albicans and candidalysin in inflammatory disorders and cancer.
Candida albicans and candidalysin in inflammatory disorders and cancer.
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DOI：
10.1111/imm.13255
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发表时间：
2021-01
期刊：
影响因子：
6.4
通讯作者：
Naglik JR
中科院分区：
文献类型：
--
作者：
Ho J;Camilli G;Griffiths JS;Richardson JP;Kichik N;Naglik JR
随着我们对真菌学的了解不断深入，真菌微生物对人类健康的影响越来越明显。白色念珠菌是一种常见的真菌，可引起局部和全身感染，特别是在免疫功能低下的患者中，可导致死亡。然而，C.白色念珠菌还与各种炎症性疾病悄悄地联系在一起，传统上认为它是偶然的;最近的研究现在可能提供了这些关系的新方面，供进一步考虑。本文对C.白色念珠菌及其肽毒素，念珠菌溶素，对人类健康的影响，探讨其在各种疾病的病理学的贡献。 白色念珠菌感染与多种炎性疾病有关。C.在这些情况下，白色念珠菌，以加强病理学探讨在这方面的审查。
As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases. Candida albicans infections have been linked with a variety of inflammatory diseases. The ability for C. albicans to potentiate pathology in these instances is explored in this review.