Fine Needle Aspiration Biopsy in Uveal Melanoma: Technique, Complications, and Outcomes
Fine Needle Aspiration Biopsy in Uveal Melanoma: Technique, Complications, and Outcomes
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DOI：
10.1016/j.ajo.2015.11.005
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发表时间：
2016-02-01
影响因子：
4.2
通讯作者：
Cassoux, Nathalie
中科院分区：
文献类型：
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作者：
Sellam, Alexandre;Desjardins, Laurence;Cassoux, Nathalie
目得：报告的技术方面，并发症，和结果有关细针穿刺活检（FNAB）在葡萄膜melanocyan.DESIGN：回顾性队列study.METHODS：葡萄膜黑色素瘤患者接受经巩膜或经玻璃体FNAB在眼科肿瘤中心进行了回顾性评价。如果肿瘤厚度超过5 mm，则进行FNAB。对具有足够组织的活检样品进行阵列比较基因组杂交分析。主要结果的措施是成功（样本，给了一个成功的结果，生物标志物分析）率，并发症，肝转移，和总survival.RESULTS：有217（114名男性，52%）的平均年龄为56.7（16-84）岁的连续研究患者。平均随访期为31个月（范围3.6-61.3）。平均肿瘤厚度为8.4（范围5-12）mm。手术的总体成功率为169例患者（77.9%）。31例患者（14.3%）发生玻璃体内出血，其中9例（4.1%）需要玻璃体手术。无眼内炎、眼眶播散、局部复发或孔源性视网膜脱离病例。32例患者（14.7%）在研究期间发生转移，其中20例（9.2%）死亡。在169例成功样本中，53例患者（31%）被归类为低风险，41例（24%）为中等风险，54例（32%）为高风险。15例患者（9%）没有任何可检测到的染色体异常和6（4%）不能被classificed.CONCLUSION：FNAB是一个相对安全和成功的技术，可以常规用于获得组织的分子基因组分析，这样的分析有助于确定葡萄膜黑色素瘤的诊断和预后。(C)2016年，Elsevier Inc. All rights reserved.
PURPOSE: To report the technical aspects, complications, and outcomes concerning fine needle aspiration biopsy (FNAB) in uveal melanoma.DESIGN: Retrospective cohort study.METHODS: Patients with uveal melanoma who underwent transscleral or transvitreal FNAB at an ocular oncology center were retrospectively evaluated. FNAB was performed if the tumor was more than 5 mm in thickness. Array comparative genomic hybridization analysis was performed on biopsy samples with sufficient tissue. The main outcome measures were success (sample that gave a successful result for biomarker analysis) rate, complications, liver metastasis, and overall survival.RESULTS: There were 217 (114 male, 52%) consecutive study patients with a mean age of 56.7 (16-84) years. The mean follow-up period was 31 (range 3.6-61.3) months. Mean tumor thickness was 8.4 (range 5-12) mm. The overall success rate of the procedure was 169 patients (77.9%). Thirty-one patients (14.3%) experienced intravitreal hemorrhage, of whom 9 (4.1%) required vitreal surgery. There was no case of endophthalmitis, orbital dissemination, local recurrence, or rhegmatogenous retinal detachment. Thirty-two patients (14.7%) developed metastasis during the study, of whom 20 (9.2%) died. Of the 169 successful samples, 53 patients (31%) were classified as low risk, 41 (24%) as intermediate risk, and 54 (32%) as high risk. Fifteen patients (9%) did not have any detectable chromosomal abnormality and 6 (4%) could not be classified.CONCLUSION: FNAB is a relatively safe and successful technique that can be routinely used to obtain tissue for molecular genomic analysis; such analysis helps determine the diagnosis and prognosis in uveal melanoma. (C) 2016 by Elsevier Inc. All rights reserved.