Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells
Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells
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DOI：
10.7554/elife.50340
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发表时间：
2020-02-26
期刊：
影响因子：
7.7
通讯作者：
Olsen, Shawn R.
中科院分区：
文献类型：
--
作者：
Garrett, Marina;Manavi, Sahar;Olsen, Shawn R.
皮质回路可以随着经验和学习而灵活变化，但对特定细胞类型（包括不同的抑制类型）的影响还不清楚。在这里，我们研究了兴奋性和VIP抑制细胞在小鼠视觉皮层的第2/3层的行为任务的背景下，视觉经验的影响。小鼠通过一组八幅自然场景图像学习视觉变化检测任务。随后，在双光子成像实验中，小鼠用这些熟悉的图像和三组新图像执行任务。引人注目的是，VIP活性的时间动态显着不同之间的新的和熟悉的图像：VIP细胞的刺激驱动的新的图像，但被抑制的熟悉的刺激，并显示斜坡活动时，预期的刺激从时间上可预测的序列省略。VIP活性的这种显著变化表明，这些细胞可能在新的与熟悉的条件下采用不同的处理模式。
Cortical circuits can flexibly change with experience and learning, but the effects on specific cell types, including distinct inhibitory types, are not well understood. Here we investigated how excitatory and VIP inhibitory cells in layer 2/3 of mouse visual cortex were impacted by visual experience in the context of a behavioral task. Mice learned a visual change detection task with a set of eight natural scene images. Subsequently, during 2-photon imaging experiments, mice performed the task with these familiar images and three sets of novel images. Strikingly, the temporal dynamics of VIP activity differed markedly between novel and familiar images: VIP cells were stimulus-driven by novel images but were suppressed by familiar stimuli and showed ramping activity when expected stimuli were omitted from a temporally predictable sequence. This prominent change in VIP activity suggests that these cells may adopt different modes of processing under novel versus familiar conditions.