Inherently stealthy and highly tumor-selective gold nanoraspberries for photothermal cancer therapy.
Inherently stealthy and highly tumor-selective gold nanoraspberries for photothermal cancer therapy.
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DOI：
10.1038/srep10311
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发表时间：
2015-05-14
影响因子：
4.6
通讯作者：
Singamaneni S
中科院分区：
文献类型：
--
作者：
Gandra N;Portz C;Nergiz SZ;Fales A;Vo-Dinh T;Singamaneni S
由于其独特的光学特性，例如大的吸收和散射截面以及表面电磁场的大幅增强，等离子体纳米结构作为一类非常有前途的纳米肿瘤材料受到了广泛的关注。大多数现有的等离子体纳米结构需要广泛的合成后处理和生物功能化程序，以减轻其细胞毒性和/或使其具有肿瘤特异性。在这里，我们报告了通过使用天然丰富的多糖壳聚糖作为模板和封端剂，一锅合成一类新型等离子体纳米结构，即具有可调尺寸和局部表面等离子体共振的金纳米树莓（GRB）。值得注意的是，GRB 不需要任何进一步的生物功能化，对肿瘤细胞表现出优异的选择性，从而能够在细胞水平上进行局部治疗。我们通过光热消融选择性地从与正常细胞共培养的肿瘤细胞中证明GRB的肿瘤选择性。 GRB 的简单、可扩展和肿瘤选择性性质使其成为基于转化等离子体的纳米医学的优秀候选者。
Owing to their unique optical properties such as large absorption and scattering cross section and large enhancement of electromagnetic field at the surface, plasmonic nanostructures have received extensive attention as a highly promising class of materials for nano-oncology. Most of the existing plasmonic nanostructures require extensive post-synthesis treatments and biofunctionalization routines to mitigate their cytotoxicity and/or make them tumor-specific. Here, we report one-pot synthesis of a novel class of plasmonic nanostructures, namely, gold nanoraspberries (GRBs) with tunable size and localized surface plasmon resonance by using a naturally abundant polysaccharide, chitosan, which acts as a template and capping agent. Significantly, the GRBs, which do not require any further biofunctionalization, exhibit excellent selectivity to tumor cells, thus enabling locoregional therapy at the cellular level. We demonstrate the tumor-selectivity of GRBs by photothermal ablation of tumor cells selectively from their co-culture with normal cells. The simple, scalable and tumor-selective nature of GRBs makes them excellent candidates for translational plasmonics-based nanomedicine.