Development of biocompatible synthetic extracellular matrices for tissue engineering
Development of biocompatible synthetic extracellular matrices for tissue engineering
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DOI：
10.1016/s0167-7799(98)01191-3
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发表时间：
1998-05-01
影响因子：
17.3
通讯作者：
Mooney, DJ
中科院分区：
文献类型：
--
作者：
Kim, BS;Mooney, DJ
组织工程可以提供器官和组织移植的替代方案，两者都受到供应的限制。使用可生物降解的合成细胞外基质的细胞移植提供了创造完全天然的新组织的可能性，从而替代丢失或功能障碍的器官或组织。由生物相容性、可生物降解的聚合物制成的合成细胞外基质在由移植细胞形成功能性新组织中起重要作用。它们提供了一个临时的支架来引导新组织的生长和组织，并可能提供旨在保持组织特异性基因表达的特定信号。
Tissue engineering may provide an alternative to organ and tissue transplantation, both of which suffer from a limitation of supply. Cell transplantation using biodegradable synthetic extracellular matrices offers the possibility of creating completely natural new tissues and so replacing lost or malfunctioning organs or tissues. Synthetic extracellular matrices fabricated from biocompatible, biodegradable polymers play an important role in the formation of functional new tissue from transplanted cells. They provide a temporary scaffolding to guide new tissue growth and organization, and may provide specific signals intended to retain tissue-specific gene expression.