Effect of Age and Myopia on Retinal Microvasculature
Effect of Age and Myopia on Retinal Microvasculature
复制标题
DOI：
10.3928/23258160-20181203-03
复制
发表时间：
2018-12-01
影响因子：
1
通讯作者：
Tsui, Irena
中科院分区：
文献类型：
--
作者：
Leng, Yunxia;Tam, Emily K.;Tsui, Irena
背景与目的：研究年龄和屈光不正对视网膜微血管网变化的影响。患者和方法：受试者从Doheny眼科研究所招募。测量屈光不正和眼轴长度。高度近视定义为屈光不正大于-6D。进行光学相干断层扫描血管造影（OCTA）成像，并使用分形分析对图像进行分析。主要结局为浅表毛细血管丛（SCP）血管密度。深毛细血管丛（DCP）血管密度和葡萄膜无血管区（FAZ）面积。28例（41%）受试者为男性，41例（59%）受试者为女性。平均年龄为42.81岁± 19.91岁（范围：8岁至87岁）。平均屈光不正为-1.74 D +/- 3.18 D（范围：-15.78 D至4.25 D），平均眼轴长度（AL）为24.29 mm +/- 1.35 mm（范围：21.73 mm至28.32 mm）。SCP和DCP血管密度与年龄呈负相关（r =-0.22，P = 0.011; r =-0.49，P = 0.001）。控制年龄，高度近视和AL较长的患者SCP密度降低（分别为P = .021和P = .027），但DCP血管密度无差异（分别为P = .065和P = .058）。FAZ面积与年龄、性别、屈光度或AL无显著相关性。结论：SCP和DCP血管密度随年龄增长而降低。此外，高度近视眼和较长的AL的SCP密度降低，但DCP血管密度不降低。
BACKGROUND AND OBJECTIVE: To investigate the effect of age and refractive error on changes in the retinal microvascular network.PATIENTS AND METHODS: Subjects wore recruited from the Doheny Eye Institute. Refractive error and axial length were measured. High myopia was defined as refractive error greater than - 6 diopters (D). Optical coherence tomography angiography (OCTA) imaging was performed and images were analyzed using fractal analysis. Primary outcomes were superficial capillary plexus (SCP) vessel density. deep capillary plexus (DCP) vessel density, and fuveal avascular zone (FAZ) area.RESULTS: One hundred thirty-eight eyes of 69 subjects were included. Twenty-eight (41%) subjects were male and 41 (59%) subjects were female. Mean age was 42.81 years +/- 19.91 years (range: 8 years to 87 years). Mean refractive error was -1.74 D +/- 3.18 D (range: -15.78 D to 4.25 D), and mean axial length (AL) was 24.29 mm +/- 1.35 mm (range: 21.73 mm to 28.32 mm). SCP and DCP vessel densities were negatively correlated to age (r = -0.22, P = .011; and r = -0.49, P < .001). Controlling for age, patients with high myopia and longer AL had decreased SCP density (P = .021 and P = .027, respectively), but no difference in DCP vessel density was observed (P = .065 and P = .058, respectively). FAZ area was not significantly correlated to age, gender, refraction, or AL.CONCLUSIONS: SCP and DCP vessel densities decreased with age. In addition, SCP density but not DCP vessel density was reduced in eyes with high myopia and longer AL.