Update on the management and treatment of viral hepatitis.
Update on the management and treatment of viral hepatitis.
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DOI：
10.3748/wjg.v27.i23.3249
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发表时间：
2021-06-21
影响因子：
4.3
通讯作者：
Boteon YL
中科院分区：
文献类型：
--
作者：
Almeida PH;Matielo CEL;Curvelo LA;Rocco RA;Felga G;Della Guardia B;Boteon YL
本文就病毒性肝炎的临床治疗进行综述。此外，未来的治疗方案和潜在的研究兴趣的领域进行了详细说明。检索PubMed和Scopus数据库中过去10年内发表的主要研究。关键词包括甲型肝炎病毒、B型肝炎病毒（HBV）、丙型肝炎病毒、丁型肝炎病毒（HDV）、戊型肝炎病毒和治疗。对研究中报告的结局进行总结、制表和合成。病毒性肝炎治疗取得了重大进展，如丙型肝炎治愈性疗法的出现以及甲型肝炎、B型肝炎和戊型肝炎疫苗接种的发展和改进。迄今为止，除了抑制病毒之外，还没有治疗B型肝炎的药物;然而，针对HBV的靶向抗病毒药物（免疫调节疗法和基因沉默技术）是根除病毒的有希望的方法。最终，高疫苗接种覆盖率和高筛查率的大规模检测和治疗方案可能会消除病毒性肝炎并减轻其对卫生系统的负担。丙型肝炎治疗的发展重新激发了人们对B肝炎治疗的热情，尽管还需要进一步的研究。针对HDV生命周期的新型治疗方案目前正在临床研究中。
This review aims to summarize the current evidence on the treatment of viral hepatitis, focusing on its clinical management. Also, future treatment options and areas of potential research interest are detailed. PubMed and Scopus databases were searched for primary studies published within the last ten years. Keywords included hepatitis A virus, hepatitis B virus (HBV), hepatitis C virus, hepatitis D virus (HDV), hepatitis E virus, and treatment. Outcomes reported in the studies were summarized, tabulated, and synthesized. Significant advances in viral hepatitis treatment were accomplished, such as the advent of curative therapies for hepatitis C and the development and improvement of hepatitis A, hepatitis B, and hepatitis E vaccination. Drugs that cure hepatitis B, going beyond viral suppression, are so far unavailable; however, targeted antiviral drugs against HBV (immunomodulatory therapies and gene silencing technologies) are promising approaches to eradicating the virus. Ultimately, high vaccination coverage and large-scale test-and-treat programmes with high screening rates may eliminate viral hepatitis and mitigate their burden on health systems. The development of curative hepatitis C treatment renewed the enthusiasm for curing hepatitis B, albeit further investigation is required. Novel therapeutic options targeting HDV life cycle are currently under clinical investigation.
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影响因子：
158.5
作者：
Gane, Edward;Lawitz, Eric;Mensa, Federico J.
通讯作者：
Mensa, Federico J.
影响因子：
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作者：
Chan, Henry L. Y.;Ahn, Sang Hoon;Cooney, Elizabeth
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
Yu, Ming-Lung
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2.7
作者：
Huang, W. J.;Zhang, H. Y.;Wang, Y. C.
通讯作者：
Wang, Y. C.