9 + 0 and 9 + 2 cilia are randomly dispersed in the mouse node.
9 + 0 and 9 + 2 cilia are randomly dispersed in the mouse node.
复制标题
9 0 和9 2 纤毛随机分散在小鼠节点中。
DOI：
10.1093/jmicro/dfv352
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kawahara T.
中科院分区：
文献类型：
--
作者：
Odate T;Takeda S;Narita K;Kawahara T.
左右不对称的最初决定是胚胎发育中的一个重要过程。在小鼠胚胎中，淋巴结中的纤毛在产生淋巴结流中起重要作用，淋巴结流随后触发胚胎中的左右决定。虽然结节纤毛历史上被认为具有9 + 0轴丝构型，但到目前为止已经报道了9 + 2纤毛的存在。由于这两种类型的纤毛在结内的分布尚未报道，我们评估了9 + 0和9 + 2纤毛在结中的排列。在本研究中，我们得出的结论是，大多数结纤毛的结构是9 + 0和9 + 2纤毛比9 + 0纤毛少得多。此外，这两种纤毛在结中的分布是随机的，没有规律性。此外，我们研究了围绕节点的冠细胞的胚胎起源，以更好地了解他们的身份。
The initial determination of left–right asymmetry is an essential process in embryonic development. In mouse embryo, cilia in the node play an important role generating the nodal flow that subsequently triggers left–right determination in the embryo. Although nodal cilia have historically been thought to have a 9 + 0 axonemal configuration, the existence of 9 + 2 cilia has been reported so far. Because the distribution of those two types of cilia within the node has not yet been reported, we assessed the arrangement of 9 + 0 and 9 + 2 cilia in the node. In this study, we concluded that most of the nodal cilia were 9 + 0 in structure and there were much fewer 9 + 2 cilia than 9 + 0 cilia. Furthermore, the two types of cilia were randomly distributed in the node with no regularity. In addition, we studied the embryonic origin of the crown cells surrounding the node to better understand their identity.