Failure of lymphokine-producing lymphocytes from aged humans to undergo activation by recall antigens.
Failure of lymphokine-producing lymphocytes from aged humans to undergo activation by recall antigens.
复制标题
老年人产生淋巴因子的淋巴细胞无法被记忆抗原激活。
DOI：
10.4049/jimmunol.124.5.2169
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发表时间：
1980
影响因子：
4.4
通讯作者：
A. Guansing
中科院分区：
文献类型：
--
作者：
P. Sohnle;S. E. Larson;C. Collins;A. Guansing
为了更好地了解老年人迟发型超敏反应减弱的原因，我们研究了10名80岁以上健康受试者的淋巴细胞功能。抗原刺激的淋巴因子产生显著减少（30例检测中有3例阳性，而年轻对照组31例中有24例阳性）是老年受试者中最显著的发现，似乎是其对回忆抗原的皮肤反应降低的最佳解释。尽管老年组中促分裂原刺激的淋巴细胞转化对前列腺素E2的抑制比年轻组更敏感，但前列腺素的直接作用似乎不能解释抗原刺激的淋巴因子反应减弱。非特异性有丝分裂原伴刀豆球蛋白A在10名老年受试者中的9名中引起了正常的淋巴因子反应，这表明老年人的淋巴细胞在受到足够刺激时具有正常的淋巴因子产生能力。因此，老年人迟发性超敏反应减少可能与淋巴因子产生不足有关，这反过来又涉及产生这些介质的淋巴细胞通过回忆抗原进行激活的能力降低。
In order to understand better the causes of diminished delayed hypersensitivity in the elderly, we studied lymphocyte function in 10 healthy subjects over 80 years of age. Markedly decreased antigen-stimulated lymphokine production (3 of 30 assays positive versus 24 of 31 in young control subjects) was the most significant finding in the elderly subjects and appeared to be the best explanation for their reduced cutaneous responses to recall antigens. Although mitogen-stimulated lymphocyte transformation in the elderly group was more sensitive to suppression by prostaglandin E2 than that of the young group, direct prostaglandin action did not appear to explain the diminished antigen-stimulated lymphokine responses. The nonspecific mitogen concanavalin A elicited normal lymphokine responses in 9 of 10 elderly subjects, indicating that lymphocytes from the elderly have a normal capacity for lymphokine production when activated by a sufficient stimulus. Therefore, diminished delayed hypersensitivity in aged humans may be related to deficient lymphokine production, which in turn appears to involve a decreased capacity of the lymphocytes producing these mediators to undergo activation by recall antigens.