A TRANSFORMING GROWTH-FACTOR-BETA TYPE-I RECEPTOR THAT SIGNALS TO ACTIVATE GENE-EXPRESSION
A TRANSFORMING GROWTH-FACTOR-BETA TYPE-I RECEPTOR THAT SIGNALS TO ACTIVATE GENE-EXPRESSION
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DOI：
10.1126/science.8272871
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发表时间：
1994-01-07
期刊：
影响因子：
56.9
通讯作者：
WANG, XF
中科院分区：
文献类型：
--
作者：
BASSING, CH;YINGLING, JM;WANG, XF
转化生长因子-β是一种多功能因子，调节细胞功能的多个方面。转化生长因子-β通过I型和II型转化生长因子-β受体的异构体复合体传递信号。然而，该受体复合体信号转导的分子机制尚不清楚。II型受体属于跨膜受体丝氨酸-苏氨酸激酶家族。该受体家族中的一个新成员(R4)被发现是一种功能性的转化生长因子-βI型受体，因为它能够在缺乏内源性I型受体的突变细胞系中恢复由转化生长因子-β诱导的基因反应。R4蛋白的配体结合和信号传递都依赖于功能性II型受体的存在。I型受体具有内在的丝氨酸-苏氨酸激酶活性，这是信号转导所必需的。
Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.