Abnormal resting-state functional connectivity of the left caudate nucleus in obsessive-compulsive disorder
Abnormal resting-state functional connectivity of the left caudate nucleus in obsessive-compulsive disorder
复制标题
DOI：
10.1016/j.neulet.2016.04.030
复制
发表时间：
2016-06-03
影响因子：
2.5
通讯作者：
Li, Ping
中科院分区：
文献类型：
--
作者：
Chen, Yunhui;Juhas, Michal;Li, Ping
皮质-纹状体-丘脑皮质（CSTC）回路中的脑活动改变与强迫症（OCD）的病理生理学有关。然而，根本的变化是否只发生在这个电路或在大规模的网络仍然没有彻底了解。本研究对30名强迫症患者和30名健康对照者的静息态功能磁共振成像（fMRI）数据进行了基于体素的功能连接分析，以探讨强迫症患者全脑内在功能连接模式。相对于健康对照组，强迫症患者表现出CSTC回路内的功能连接减少，但其他脑区的功能连接增加。此外，CSTC回路中左侧尾状核-丘脑连接性的降低与强迫症的病程呈正相关。这项研究提供了额外的证据，CSTC电路可能发挥重要作用，大规模的大脑网络的改变可能参与了强迫症的病理生理。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Altered brain activities in the cortico-striato-thalamocortical (CSTC) circuitry are implicated in the pathophysiology of obsessive-compulsive disorder (OCD). However, whether the underlying changes occur only within this circuitry or in large-scale networks is still not thoroughly understood. This study performed voxel-based functional connectivity analysis on resting-state functional magnetic resonance imaging (fMRI) data from thirty OCD patients and thirty healthy controls to investigate whole-brain intrinsic functional connectivity patterns in OCD. Relative to the healthy controls, OCD patients showed decreased functional connectivity within the CSTC circuitry but increased functional connectivity in other brain regions. Furthermore, decreased left caudate nucleus-thalamus connectivity within the CSTC circuitry was positively correlated with the illness duration of OCD. This study provides additional evidence that CSTC circuitry may play an essential role and alteration of large-scale brain networks may be involved in the pathophysiology of OCD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.