Cellular interactions in the corpus luteum.
Cellular interactions in the corpus luteum.
复制标题
黄体中的细胞相互作用。
DOI：
10.1055/s-2008-1068376
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Reynolds,LP
中科院分区：
文献类型：
--
作者：
Grazul-Bilska,AT;Redmer,DA;Reynolds,LP
黄体（CL）是一个器官，在每个非妊娠周期的过程中表现出非常快速的生长，发育和退化。CL由类固醇生成（实质）和非类固醇生成（非实质）细胞组成。小实质细胞和大实质细胞在许多形态和功能特征上不同，并且被认为彼此相互作用以维持正常的黄体功能。这些类固醇生成黄体细胞也与非类固醇生成细胞相互作用;例如，它们产生刺激内皮细胞增殖和迁移以及成纤维细胞增殖的因子;它们也可以增强或抑制免疫细胞功能。相反，内皮细胞产生调节类固醇生成的因子，免疫细胞产生改变类固醇生成细胞的分泌功能的细胞因子。细胞间的相互作用可能由几种机制介导，包括体液（内分泌和旁分泌）途径以及接触依赖性（缝隙连接）途径。因此，由类固醇生成或非类固醇生成细胞局部产生的激素、生长因子和细胞因子可以在细胞间间接或直接转移以调节黄体功能。缝隙连接存在于几个物种的黄体组织中，并且缝隙连接的细胞间通讯受到黄体发育阶段以及黄体功能的系统和局部调节剂的影响。这种细胞间的相互作用可能是重要的黄体激素的生产，信号转导，血管生成，和黄体溶解，因为它们的作用，协调功能之间的各种黄体细胞类型。
The corpus luteum (CL) is an organ that exhibits extremely rapid growth, development, and regression during the course of each nonpregnant cycle. The CL consists of steroidogenic (parenchymal) and nonsteroidogenic (nonparenchymal) cells. The small and large parenchymal cells differ in numerous morphological and functional characteristics, and are thought to interact with each other to maintain normal luteal function. These steroidogenic luteal cells also interact with the nonsteroidogenic cells; for example, they produce factors that stimulate proliferation and migration of endothelial cells and proliferation of fibroblasts; they also may enhance or suppress immune cell fiinction. Conversely, endothelial cells produce factors that modulate steroidogenesis, and immune cells produce cytokines that modify the secretory function of steroidogenic cells. Cellular interactions may be mediated by several mechanisms, including humoral (endocrine and paracrine) pathways as well as contact-dependent (gap junctional) pathways. Thus, hormones, growth factors and cytokines produced locally by steroidogenic or nonsteroidogenic cells may be transferred from cell to cell indirectly or directly to regulate luteal function. Gap junctions are present in luteal tissues of several species, and gap junctional intercellular communication is affected by the stage of luteal development and systemic and local regulators of luteal function. Such cellular interactions probably are important in luteal hormone production, signal transduction, angiogenesis, and luteolysis because of their role in coordinating function among the various luteal cell types.