Involvement of estrogen receptor α, β and oxytocin in social discrimination:: a detailed behavioral analysis with knockout female mice
Involvement of estrogen receptor α, β and oxytocin in social discrimination:: a detailed behavioral analysis with knockout female mice
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DOI：
10.1111/j.1601-183x.2006.00203.x
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发表时间：
2006-10-01
影响因子：
2.5
通讯作者：
Pfaff, D. W.
中科院分区：
文献类型：
--
作者：
Choleris, E.;Ogawa, S.;Pfaff, D. W.
社会认知、处理和保留关于同种个体的信息对于正常社会关系的发展至关重要。神经肽催产素（OT）是雄性和雌性小鼠社会识别所必需的，其作用受到雌性雌激素的调节。在先前的研究中，其雌激素受体-α（α-ERKO）和雌激素受体-β（β-ERKO）以及OTKO的基因被敲除的小鼠不能习惯于重复呈现的同种，并且当熟悉的小鼠被新动物替代时不能适应（Choleris等，2003，Proc Natl Acad Sci USA 100，6192-6197）。然而，一个二元社会歧视测试，其中动物同时在熟悉的和以前未知的个体之间进行选择，提供了一个更直接的社会识别测试。在这里，我们在二元社会歧视范式中使用了α-ERKO、β-ERKO和OTKO雌性小鼠。与野生型对照相比，当给予选择时，KO小鼠显示出减少的（β-ERKO）或完全受损的（OTKO和α-ERKO）社会歧视。详细的行为分析表明，所有KO小鼠对社会刺激的焦虑相关拉伸方法减少，水平和垂直活动，非社会调查和各种其他行为（如自我梳理，挖掘和不活动）没有整体损害。因此，OT、ER-α和ER-β基因在不同程度上对于社会歧视以及社会行为（例如攻击性、隶属关系）的调节是必要的。
Social recognition, processing, and retaining information about conspecific individuals is crucial for the development of normal social relationships. The neuropeptide oxytocin (OT) is necessary for social recognition in male and female mice, with its effects being modulated by estrogens in females. In previous studies, mice whose genes for the estrogen receptor-alpha (alpha-ERKO) and estrogen receptor-beta (beta-ERKO) as well as OTKO were knocked out failed to habituate to a repeatedly presented conspecific and to dishabituate when the familiar mouse is replaced by a novel animal (Choleris et al. 2003, Proc Natl Acad Sci USA 100, 6192-6197). However, a binary social discrimination assay, where animals are given a simultaneous choice between a familiar and a previously unknown individual, offers a more direct test of social recognition. Here, we used alpha-ERKO, beta-ERKO, and OTKO female mice in the binary social discrimination paradigm. Differently from their wild-type controls, when given a choice, the KO mice showed either reduced (beta-ERKO) or completely impaired (OTKO and alpha-ERKO) social discrimination. Detailed behavioral analyses indicate that all of the KO mice have reduced anxiety-related stretched approaches to the social stimulus with no overall impairment in horizontal and vertical activity, non-social investigation, and various other behaviors such as, self-grooming, digging, and inactivity. Therefore, the OT, ER-alpha, and ER-beta genes are necessary, to different degrees, for social discrimination and, thus, for the modulation of social behavior (e.g. aggression, affiliation).