Visible-Light-Mediated Charge Transfer Enables C-C Bond Formation with Traceless Acceptor Groups
Visible-Light-Mediated Charge Transfer Enables C-C Bond Formation with Traceless Acceptor Groups
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DOI：
10.1002/chem.201901397
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发表时间：
2019-06-21
影响因子：
4.3
通讯作者：
Glorius, Frank
中科院分区：
文献类型：
--
作者：
James, Michael J.;Strieth-Kalthoff, Felix;Glorius, Frank
介绍了光化学C-C键形成中无迹受体基团的发展和应用。这一策略是通过电子给体-受体(EDA)络合物与可见光的光激发而实现的。以氨基酸和多肽为原料制备的无迹受体，在无金属和无过氧化氢的条件下，可用于多种杂芳烃和烯胺供体的烷基化反应。通过实验和计算相结合的研究，探讨了EDA络合物在这些反应机理中的关键作用。
The development and application of traceless acceptor groups in photochemical C-C bond formation is described. This strategy was enabled by the photoexcitation of electron donor-acceptor (EDA) complexes with visible light. The traceless acceptors, which were readily prepared from amino acid and peptide feedstocks, could be used to alkylate a wide range of heteroarene and enamine donors under metal- and peroxide-free conditions. The crucial role of the EDA complexes in the mechanism of these reactions was explored through combined experimental and computational studies.