DNase1L3 suppresses hepatocellular carcinoma growth via inhibiting complement autocrine effect
DNase1L3 suppresses hepatocellular carcinoma growth via inhibiting complement autocrine effect
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DNase1L3 通过抑制补体自分泌作用抑制肝细胞癌生长
DOI：
10.4149/neo_2021_201010n1069
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发表时间：
2021-01-01
期刊：
影响因子：
3
通讯作者：
Suo, Da-Qin
中科院分区：
文献类型：
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作者：
Chen, Qing-Yun;Li, Lei;Suo, Da-Qin
肝细胞癌（HCC）是最具侵袭性的癌症类型之一，目前缺乏有效的治疗策略。本研究表明，脱氧核糖核酸酶 1 样 3 (DNase1L3) 表达水平在多种类型的胃肠道癌症中显着下调，尤其是在 HCC 中。组织微阵列进一步表明，与正常肝组织相比，HCC 组织中 DNase1L3 表达水平经常下调。此外，DNase1L3 表达水平被确定与肿瘤大小 (p=0.0028)、肿瘤血栓形成 (p
Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and currently lacks effective treatment strategies. The present study revealed that deoxyribonuclease 1 like 3 (DNase1L3) expression levels were significantly downregulated in numerous types of gastrointestinal cancer, and especially in HCC. Tissue microarrays were further used to illustrate that DNase1L3 expression levels were frequently downregulated in HCC tissues compared with normal liver tissues. In addition, DNase1L3 expression levels were identified to be significantly associated with tumor size (p=0.0028), tumor thrombus formation (p