Influence of Auditory Stimulation Rates on Evoked Potentials during General Anesthesia Relation between the Transient Auditory Middle-latency Response and the 40-Hz Auditory Steady State Response
Influence of Auditory Stimulation Rates on Evoked Potentials during General Anesthesia Relation between the Transient Auditory Middle-latency Response and the 40-Hz Auditory Steady State Response
复制标题
DOI：
10.1097/aln.0b013e31819dad6f
复制
发表时间：
2009-05-01
期刊：
影响因子：
8.8
通讯作者：
Oezdamar, Oezcan
中科院分区：
文献类型：
--
作者：
McNeer, Richard R.;Bohorquez, Jorge;Oezdamar, Oezcan
背景：听觉中潜伏期反应（transient）和40 hz听觉稳态反应（ASSR）是由麻醉剂调节的。然而，由于记录方法的技术限制，很难获得这些诱发反应之间的定量关系，这些方法用于获得高刺激率下的瞬态。本研究使用连续环平均反褶积来填补这一技术空白，并研究了全麻时瞬态和ASSR波形之间的关系。方法：记录13例全麻状态下的5hz、40hz瞬态和40hz assr。利用5 hz和40 hz的瞬态波形线性叠加来预测40 hz的ASSR。使用相量分析和Hotelling T-2分析对预测和记录的assr进行分析和比较。结果：大平均记录显示5- hz和40-Hz瞬态的早期中潜伏期峰存在差异，例如，P-x峰仅在5- hz瞬态中存在。只有从40-Hz瞬态得到的预测40-Hz ASSR与实际ASSR匹配。相量分析表明，早期峰值对稳态波形有显著贡献，这解释了为什么5hz瞬态不能预测40hz ASSR。麻醉期间观察到5 hz和40 hz瞬态振荡。讨论：40-Hz ASSR代表一种复合波形，当40-Hz刺激率引发的瞬态波形重叠和叠加时产生。在全身麻醉时，瞬态的形态取决于刺激呈现的速率。ASSR的复合性质可以解释其他人观察到的非单调麻醉剂量-反应关系。
Background: The auditory middle-latency response (transient) and the 40-Hz auditory steady state response (ASSR) are modulated by anesthetics. However, the quantitative relation between these evoked responses is difficult to obtain because of technical limitations of the recording methods used to obtain transients at high stimulation rates. This study uses continuous- loop averaging deconvolution to fill this technical gap and to study the relation between the transient and ASSR waveform during general anesthesia.Methods: The authors recorded 5- and 40-Hz transients and 40-Hz ASSRs in 13 subjects during general anesthesia. The 5- and 40-Hz transients were used to predict the 40-Hz ASSR by linearly superimposing the transient waveforms. The predicted and recorded ASSRs were analyzed and compared using phasor and Hotelling T-2 analyses.Results: Grand-averaged recordings revealed differences in the early middle-latency peaks between 5- and 40-Hz transients, e.g., the peak P-x was present only in 5-Hz transient. Only the predicted 40-Hz ASSR derived from the 40-Hz transient matched the actual ASSR. Phasor analysis showed that the early peaks contribute significantly to the steady state waveform, and this explains why 5-Hz transient does not predict the 40-Hz ASSR. Oscillations in both the 5- and 40-Hz transients were observed during anesthesia.Discussion: The 40-Hz ASSR represents a composite waveform and arises when transient waveforms elicited with a 40-Hz stimulation rate are overlapped and superimposed. During general anesthesia, the morphology of the transient is dependent on the rate of stimulus presentation. The composite nature of the ASSR may explain nonmonotonic anesthetic dose-response relations observed by others.