T-Epitope Designer: A HLA-peptide binding prediction server.
T-Epitope Designer: A HLA-peptide binding prediction server.
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DOI：
10.6026/97320630001021
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发表时间：
2005-05-15
期刊：
影响因子：
1.9
通讯作者：
Sakharkar MK
中科院分区：
文献类型：
--
作者：
Kangueane P;Sakharkar MK
目前合成疫苗设计中的挑战是开发一种方法来识别和测试作为潜在T细胞表位的短抗原肽。最近，我们描述了一种(利用结构特性)能够预测与任何HLA等位基因结合的多肽的人类白细胞抗原-多肽结合模型。因此，我们开发了一个名为T-表位设计器的Web服务器来帮助预测人类白细胞抗原多肽的结合。预测服务器基于一个模型，该模型使用从人类白细胞抗原-多肽复合体的X射线晶体结构中收集的信息来定义多肽结合口袋，然后估计多肽与结合口袋的结合。因此，预测服务器能够计算与HLA等位基因结合的多肽。这个模型优于许多现有的方法，因为它可以应用于任何给定的、序列定义明确的等位基因。该Web服务器在T细胞表位疫苗设计中具有潜在的应用前景。Http://www.bioinformation.net/ted/
The current challenge in synthetic vaccine design is the development of a methodology to identify and test short antigen peptides as potential T-cell epitopes. Recently, we described a HLA-peptide binding model (using structural properties) capable of predicting peptides binding to any HLA allele. Consequently, we have developed a web server named T-EPITOPE DESIGNER to facilitate HLA-peptide binding prediction. The prediction server is based on a model that defines peptide binding pockets using information gleaned from X-ray crystal structures of HLA-peptide complexes, followed by the estimation of peptide binding to binding pockets. Thus, the prediction server enables the calculation of peptide binding to HLA alleles. This model is superior to many existing methods because of its potential application to any given HLA allele whose sequence is clearly defined. The web server finds potential application in T cell epitope vaccine design. http://www.bioinformation.net/ted/