The scope of antibody catalysis.
The scope of antibody catalysis.
复制标题
抗体催化的范围。
DOI：
10.1016/0959-440x(95)80016-6
复制
发表时间：
1995
影响因子：
6.8
通讯作者：
Schultz,PG
中科院分区：
文献类型：
--
作者：
Jacobsen,JR;Schultz,PG
半抗原设计的新策略已经产生了通过日益复杂的机制催化反应并大幅提高催化速率的抗体。合理设计还被用来引发催化抗体，用于困难的化学转化以及未知酶的反应。这些实验证明了经过适当机械指导的大型组合库的化学潜力。
New strategies for hapten design have led to antibodies that catalyze reactions by increasingly complex mechanisms and with large increases in catalytic rate. Rational design has also been used to elicit catalytic antibodies for difficult chemical transformations as well as reactions for which no enzyme is known. These experiments have demonstrated the chemical potential of large combinatorial libraries that have been given appropriate mechanistic instruction.