D-psicose inhibits intestinal α-glucosidase and suppresses glycemic response after carbohydrate ingestion in rats
D-psicose inhibits intestinal α-glucosidase and suppresses glycemic response after carbohydrate ingestion in rats
复制标题
D-阿洛酮糖抑制肠道 α-葡萄糖苷酶并抑制大鼠摄入碳水化合物后的血糖反应
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
K. Izumori
中科院分区：
文献类型：
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作者：
T. Matsuo;K. Izumori
D-阿洛酮糖是一种罕见的糖，在商业碳水化合物和农产品中存在少量。在本研究中，我们在体外研究了D-阿洛酮糖对α-淀粉酶和α-葡萄糖苷酶活性的影响，并在体内使用大鼠评价了D-阿洛酮糖对餐后血糖反应的影响。在体外研究中，D-阿洛酮糖有效地抑制肠道蔗糖酶和麦芽糖酶，然而，轻微地抑制肠道和唾液α-淀粉酶活性。雄性Wistar大鼠（6月龄）分别给予2g/kg蔗糖、麦芽糖或可溶性淀粉以及0. 2 g/kg D-阿洛酮糖或D-果糖。D-阿洛酮糖显著抑制蔗糖或麦芽糖引起的血糖浓度升高。D-阿洛酮糖有抑制淀粉诱导的血糖反应的趋势，但抑制作用不显著。这些结果表明，D-阿洛酮糖抑制肠道蔗糖酶和麦芽糖酶的活性在一个非竞争性的方式，并抑制血糖升高后，蔗糖和麦芽糖摄入。因此，D-阿洛酮糖可用于预防糖尿病患者摄入含有蔗糖和麦芽糖的食物时的餐后高血糖。
D-Psicose is one of rare sugars present in small quantities in commercial carbohydrates and agricultural products. In this study, we investigate the effects of D-psicose on the activities of a -amylases and a -glucosidases in vitro, and evaluate the effects of D-psicose on postprandial glycemic response using rats in vivo. In vitro study, D-psicose potently inhibited intestinal sucrase and maltase, however, slightly inhibited intestinal and salivary a -amylase activities. Male Wistar rats (6 months old) were administrated 2 g/kg of sucrose, maltose or soluble starch together with 0. 2 g/kg of D-psicose or D-fructose. D-Psicose significantly inhibited the increment of plasma glucose concentration induced by sucrose or maltose. Starch-induced glycemic response tended to be suppressed by D-psicose, however the suppression was not significant. These results suggest that D-psicose inhibits intestinal sucrase and maltase activities in an uncompetitive manner and suppresses the plasma glucose increase after sucrose and maltose ingestion. Thus, D-psicose may be useful in preventing postprandial hyperglycemia in diabetic patients when foods containing sucrose and maltose are ingested.