The effect of ACTH on HMG-CoA reductase activity in hamster adrenals.

The effect of ACTH on HMG-CoA reductase activity in hamster adrenals.
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ACTH 对仓鼠肾上腺 HMG-CoA 还原酶活性的影响。

DOI:
10.1016/0024-3205(81)90524-5
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发表时间:
1981
期刊:
影响因子:
6.1
通讯作者:
A. Lefèbvre
A. Lefèbvre
中科院分区:
医学2区
文献类型:
--
作者:
J. Lehoux;A. Lefèbvre

文献摘要

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注射各种低剂量的促肾上腺皮质激素导致肾上腺HMG-CoA还原酶活性逐渐增加,血浆和肾上腺皮质类固醇浓度,但肾上腺胆固醇含量没有变化。这些数据表明,在生理条件下,促肾上腺皮质激素可以调节HMG-CoA还原酶的活性,通过一种机制,这显然并不涉及在腺体的胆固醇含量的变化。
Injection to hamsters of various low doses of ACTH resulted in gradual increases in adrenal HMG-CoA reductase activity, in plasma and adrenal corticosteroid concentrations but produced no change in adrenal cholesterol content. These data indicate that under physiological conditions, ACTH could regulate HMG-CoA reductase activity through a mechanism which does no apparently involve a change in the cholesterol content of the gland.