Mitogen-activated protein kinase kinase 7 in inflammatory, cancer, and neurological diseases.
Mitogen-activated protein kinase kinase 7 in inflammatory, cancer, and neurological diseases.
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DOI：
10.3389/fcell.2022.979673
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
应激活化的丝裂原活化蛋白激酶激酶7（MKK 7）是双特异性丝裂原活化蛋白激酶家族的成员。在人体中，MKK 7控制着基本的生理过程，包括但不限于多种组织和器官中的增殖和分化。MKK 7与MKK 4通路沿着参与了由c-Jun N-末端激酶（JNK）信号传导介导的应激活化活性和生物学事件。虽然已经进行了许多研究来确定JNK在多种生物过程中的作用，但专注于剖析MKK 7的独立作用的出版物有限。最近的研究结果刺激了通过体内遗传缺陷模型进行测试，揭示了以前未记录的MKK 7的JNK独立功能。在这里，我们讨论了JNK依赖性和非依赖性的MKK 7在体内的功能。本文综述了MKK 7在炎症、细胞因子产生、癌症和神经系统疾病中的作用。
Stress-activated mitogen-activated protein kinase kinase 7 (MKK7) is a member of the dual-specificity mitogen-activated protein kinase family. In the human body, MKK7 controls essential physiological processes, including but not limited to proliferation and differentiation in multiple tissues and organs. MKK7, along with the MKK4 pathway, has been implicated in stress-activated activities and biological events that are mediated by c-Jun N-terminal kinase (JNK) signaling. Although numerous studies have been performed to identify the role of JNK in multiple biological processes, there are limited publications that focus on dissecting the independent role of MKK7. Recent research findings have spurred testing via in vivo genetically deficient models, uncovering previously undocumented JNK—independent functions of MKK7. Here we discuss both JNK—dependent and—independent functions of MKK7 in vivo. This review summarizes the role of MKK7 in inflammation, cytokine production, cancer, and neurological diseases.
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影响因子：
4.9
作者：
Lee SI;Boyle DL;Berdeja A;Firestein GS
通讯作者：
Firestein GS
影响因子：
4.6
作者：
Yamasaki T;Deki-Arima N;Kaneko A;Miyamura N;Iwatsuki M;Matsuoka M;Fujimori-Tonou N;Okamoto-Uchida Y;Hirayama J;Marth JD;Yamanashi Y;Kawasaki H;Yamanaka K;Penninger JM;Shibata S;Nishina H
通讯作者：
Nishina H
DOI：
10.1111/gtc.12816
发表时间：
2021-01
期刊：
Genes to cells : devoted to molecular & cellular mechanisms
影响因子：
--
作者：
Shin T;Hiraoka Y;Yamasaki T;Marth JD;Penninger JM;Kanai-Azuma M;Tanaka K;Kofuji S;Nishina H
通讯作者：
Nishina H
影响因子：
9.8
作者：
Feltrin D;Fusco L;Witte H;Moretti F;Martin K;Letzelter M;Fluri E;Scheiffele P;Pertz O
通讯作者：
Pertz O