Feasibility and safety of longitudinal magnetic resonance imaging in a rodent model with intracortical microwire implants
Feasibility and safety of longitudinal magnetic resonance imaging in a rodent model with intracortical microwire implants
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DOI：
10.1088/1741-2560/6/3/034001
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发表时间：
2009-06-01
影响因子：
4
通讯作者：
Clement, R. S.
中科院分区：
文献类型：
--
作者：
Paralikar, K. J.;Neuberger, T.;Clement, R. S.
本通信的目的是研究（1）在植入适于MRI兼容性的微丝电极的动物中进行纵向磁共振成像（MRI）研究的可行性，（2）MRI研究对神经生理记录质量的影响，（3）使用MRI研究由于电极插入引起的组织损伤的程度和恢复，以及（4）由于MRI引起的组织学组织损伤。没有证据表明通过使用任何测量方法重复MRI导致慢性神经损伤，也没有统计学差异表明接受MRI扫描的动物和未接受MRI扫描的动物之间的电生理记录质量。
The Purpose of this communication is to investigate (1) the feasibility of carrying Out longitudinal magnetic resonance imaging (MRI) Studies in animals with implanted microwire electrodes adapted for MRI compatibility, (2) the effect of MRI Studies on the quality of neurophysiological recordings, (3) the use of MRI to Study the extent and recovery Of tissue damage due to electrode insertion and (4) histological tissue damage due to MRI. There was no evidence of chronic neural damage caused by repeated MRI by any of the measures used nor my statistical difference ill the quality of the electrophysiological recordings between animals that had undergone MRI scans and those that had not.