Structure of the expanded state of tomato bushy stunt virus
Structure of the expanded state of tomato bushy stunt virus
复制标题
番茄丛矮病毒扩展状态的结构
作者：
I. Robinson;S. Harrison
番茄浓密矮化病毒的完整三维结构测定表明，其蛋白质亚基如何适应病毒外壳中的不同包装环境，以及如何明确地确定颗粒的大小。在 pH 值高于中性且不存在二价阳离子的情况下，病毒的可逆、协同扩张需要亚基的进一步键合替代方案。我们在这里报告了扩大的番茄浓密矮化病毒颗粒的结构，通过 X 射线晶体学以 8 Å 分辨率测定。亚基构象变化是局部的，折叠域本质上是不变的。亚基的键合特性可以解释组件的受控多态性。
The full three-dimensional structure determination of tomato bushy stunt virus has shown how its protein subunit can accommodate to different packing environments in the viral coat and how the size of the particle is nonetheless determined without ambiguity. Reversible, cooperative expansion of the virus at pH values above neutrality and in the absence of divalent cation requires further bonding alternatives for the subunit. We report here the structure of the expanded tomato bushy stunt virus particle, determined at 8 Å resolution by X-ray crystallography. Subunit conformational changes are localized, and folded domains are essentially invariant. The bonding properties of the subunit can account for controlled polymorphism of the assembly.
影响因子：
3.4
作者：
S. Harrison
通讯作者：
S. Harrison