Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell-cell adhesion through N-cadherin.
Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell-cell adhesion through N-cadherin.
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DOI：
10.1016/j.jdsr.2017.10.001
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Ishisaki A
中科院分区：
文献类型：
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作者：
Chosa N;Ishisaki A
间充质干细胞(MSCs)具有自我更新和分化为间充质细胞的能力。因此，人骨髓间充质干细胞是用于再生医学和细胞治疗的合适候选细胞。当被组织损伤激活时，MSCs通过自我更新、迁移和分化等多种过程促进组织修复。然而，在细胞倍增过程中，自我更新和多系分化潜能的丧失以很高的速度发生。有效的MSC治疗需要建立新的技术，在长时间的细胞扩增后保持MSC的多能性。在这里，描述了两种维持MSCs干细胞干性的新机制，一种是通过SCRG1/骨髓基质细胞抗原1(BST1)的配体-受体结合，另一种是通过N-钙粘素的细胞-细胞黏附。这两种机制的发现为再生医学和细胞治疗方法提供了有价值的工具，这些方法需要在保持自然干细胞潜力的同时体外扩增人MSCs。
Mesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use in regenerative medicine and cell therapies. Upon activation by tissue damage, MSCs contribute to tissue repair through a multitude of processes such as self-renewal, migration, and differentiation. However, loss of self-renewal and multi-lineage differentiation potential occurs at a high rate during cell doubling. Effective MSC therapies require the establishment of new techniques that preserve MSC multipotency after lengthy cell expansions. Here, two novel mechanisms are described for maintenance of stemness in MSCs via scrapie responsive gene 1 (SCRG1)/bone marrow stromal cell antigen-1 (BST1) ligand–receptor combination and cell–cell adhesion through N-cadherin. These two mechanisms findings provide a valuable tool for regenerative medicine and cell therapeutic methods that require the ex vivo expansion of human MSCs while maintaining native stem cell potential.