Function and structure in the chronically isolated lumbo‐sacral spinal cord of the dog
Function and structure in the chronically isolated lumbo‐sacral spinal cord of the dog
复制标题
狗长期离体腰骶脊髓的功能和结构
DOI：
10.1002/cne.900670107
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发表时间：
1937
影响因子：
2.5
通讯作者：
S. S. Tower
中科院分区：
文献类型：
--
作者：
S. S. Tower
如果通过切断传入神经冲动的通路来分离脊髓的一部分而使动物存活，可能会回答以下问题：首先，这种功能上分离的神经组织能够存活吗？它经历了什么样的结构改变？第二，分离的神经组织是否表现出活动；脊髓是原生的吗？第三，所谓非神经组织的营养控制是由神经系统行使的，由神经组织的物理完整性，凭借某种营养关系，还是源于神经活动发起的。最后一个问题只有在神经组织存活但不活跃的情况下才能回答。如果脊髓前根完全是传出的，则可以分离一段脊髓及其传出神经纤维。六周大的小狗，也就是一窝小狗，被用来做实验。在乙醚麻醉下的一期手术中，腰部和骶背部根在两侧的膜内切开，并在上下横切脊髓。尸检显示，每个病例的上部横断位于最后一段胸椎和第一段腰椎之间，前两只动物的下部横断位于最后一段骶骨，第三只动物的下部横断位于骶骨中部。
Could a portion of the spinal cord be isolated by cutting the pathways of incoming nerve impulses and the animal be kept alive, the following questions might be answered: First, is such functionally isolated nervous tissue capable of surviving and what structural alterations does it undergo ? Second, does the isolated nervous tissue exhibit activity; 5s the spinal cord autochthonous? Third, is the so-called trophic control of non-nervous tissues by the nervous system exercised by physical integrity of the nervous tissue, by virtue of some nutritional relationship, or does it derive from activity nervously initiated. This last question may be answered only if the nervous tissue survives but is inactive. If the anterior spinal roots are entirely efferent, the isolation of a length of spinal cord together with its efferent nerve fibers is possible. Six-week-old puppies, litter mates, were used for the attempt. In a one-stage operation under ether anaesthesia the lumbar and sacral dorsal roots were cut intradurally on both sides and the cord transected above and below. Autopsy showed that the upper transection fell between the last thoracic and first lumbar se,ments in each case, and the lower transection in the last sacral segment in the first two animals and in the mid-sacral region in the third.