Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease
Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease
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DOI：
10.1016/s0021-9150(96)05994-1
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发表时间：
1997-02-10
期刊：
影响因子：
5.3
通讯作者：
Baumstark, MW
中科院分区：
文献类型：
--
作者：
Halle, M;Konig, D;Baumstark, MW
研究发现，血清铁蛋白浓度升高至 200 至 500 μg/l 之间是芬兰男性急性心肌梗死的一个强烈危险因素，但这种关联的原因仍不确定。在芬兰人群中，铁蛋白浓度与胰岛素抵抗综合征的因素相关。由于这些因素被发现与小而密的 LDL 颗粒浓度增加的 LDL 亚组分表型相关，因此我们假设铁蛋白与致动脉粥样硬化的 LDL 亚组分谱之间存在关联，这一发现可以解释观察到的铁蛋白与动脉粥样硬化之间的关系。因此，我们测定了 93 名没有感染或冠心病迹象的健康男性的血清铁蛋白水平、代谢性心血管危险因素和 LDL 亚组分表型；我们发现铁蛋白水平中度升高（200-500μg/l；n = 31）的男性比铁蛋白水平较低的男性（<200μg/l；n = 62）的冠心病风险显着更差。铁蛋白浓度升高与血清甘油三酯、VLDL 胆固醇、VLDL 载脂蛋白 B (P < 0.01)、IDL 胆固醇、空腹血糖 (P < 0.05) 和尿酸 (P < 0.01) 的值显着升高相关，而 HDL2b 和 HDL2a 胆固醇、载脂蛋白 A-I (P < 0.05) 和脂蛋白 (a) (P < 0.05) 的水平较低。 0.01）。然而，铁蛋白水平升高与小而密的 LDL 颗粒浓度增加的不利 LDL 亚组分谱无关。 (C) 1997 爱思唯尔科学爱尔兰有限公司
Elevated serum ferritin concentrations between 200 and 500 mu g/l have been found to be a strong risk factor for acute myocardial infarction in Finnish men, but the reason for this association is still uncertain. In the Finnish population ferritin concentrations correlated with factors of insulin resistance syndrome. As these factors have been found to be associated with an LDL subfraction phenotype of increased concentrations of small, dense LDL particles, we hypothesized an association between ferritin and an atherogenic LDL subfraction profile, a finding which could be an explanation for the observed relationship between ferritin and atherosclerosis. Therefore we determined serum ferritin levels, metabolic cardiovascular risk factors, and the LDL subfraction phenotype in 93 healthy men without signs for infection or coronary heart disease; We found that men with moderately elevated ferritin levels (200-500 mu g/l; n = 31) had a significantly worse coronary risk profile than men with lower levels (< 200 mu g/l; n = 62). Elevated ferritin concentrations were associated with significantly higher values for serum triglycerides, VLDL cholesterol, VLDL apolipoprotein B (P < 0.01), IDL cholesterol, fasting glucose (P < 0.05) and uric acid (P < 0.01), and lower levels for HDL2b and HDL2a cholesterol and apolipoprotein A-I (P < 0.05), and lipoprotein(a) (P < 0.01). Elevated ferritin levels were, however, not associated with an unfavourable LDL subfraction profile of increased concentrations of small, dense LDL particles. (C) 1997 Elsevier Science Ireland Ltd.