INDUCER LYMPHOCYTES-T SYNTHESIZE A FACTOR THAT STIMULATES PROLIFERATION OF CLONED MAST-CELLS
INDUCER LYMPHOCYTES-T SYNTHESIZE A FACTOR THAT STIMULATES PROLIFERATION OF CLONED MAST-CELLS
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DOI：
10.1038/291332a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
CANTOR, H
中科院分区：
文献类型：
--
作者：
NABEL, G;GALLI, SJ;CANTOR, H
诱导T淋巴细胞激活其他细胞分裂并表达新功能。已知的靶细胞包括其他淋巴细胞和造血干细胞。诱导 T 细胞显然作用于另一个重要的目标群体——肥大细胞。肥大细胞在速发型超敏反应的表达中发挥核心作用，并且在 T 细胞介导的迟发型反应中发挥重要作用。由于分化细胞的增殖通常受到可溶性生长因子的调节，因此检查了诱导 T 细胞克隆刺激肥大细胞增殖的能力。克隆的[小鼠] Ly1+2-诱导T细胞产生一种因子，选择性诱导形态和核型正常的小鼠肥大细胞克隆增殖。诱导 T 细胞可以通过释放刺激肥大细胞分裂的可溶性生长因子来调节肥大细胞数量。由于肥大细胞产物也会影响某些 T 细胞功能，因此肥大细胞-T 细胞相互作用可能构成免疫调节回路的一部分。
Inducer T lymphocytes activate other cells to divide and express new function. Known target cells include other lymphocytes and hematopoietic stem cells. The inducer T cell evidently acts on another important target population, mast cells. Mast cells have a central role in the expression of immediate hypersensitivity and are prominent in T cell mediated reactions of the delayed type. Because the proliferation of differentiated cells is often regulated by soluble growth factors, an inducer T cell clone was examined for its ability to stimulate mast cell proliferation. Cloned [mouse] Ly1+2- inducer T cells produced a factor that selectively induces morphologically and karyotypically normal mouse mast cell clones to proliferate. Inducer T cells may regulate mast cell numbers by releasing a soluble growth factor that stimulates them to divide. Because mast cell products also affect certain T cell functions, mast cell-T cell interactions may comprise part of an immunoregulatory circuit.