About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-α gene (ESRI) in breast cancer
About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-α gene (ESRI) in breast cancer
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DOI：
10.1016/j.mce.2004.02.021
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发表时间：
2004-04-30
影响因子：
4.1
通讯作者：
Leclercq, G
中科院分区：
文献类型：
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作者：
Lacroix, M;Leclercq, G
在乳腺肿瘤和乳腺癌细胞（BCC）系中，基因芯片分析显示一系列基因的表达与雌激素受体α（ER -α）基因ESR1密切相关。其中三个基因，GATA3、HNF3A（也称为FOXA1）和XBP1编码转录因子。在此，我们介绍这些因子，并讨论它们在乳腺癌细胞中ER -α介导的作用中可能的参与情况。我们特别展示了这些因子与雌激素诱导的三叶因子TFF1之间存在的或可能存在的关系。（C）2004爱思唯尔爱尔兰有限公司。保留所有权利。
In breast tumours and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the oestrogen receptor-alpha (ER-alpha) gene, ESR1. Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors. Here, we present these factors and we discuss their potential involvement in the ER-alpha-mediated actions in BCC. We notably show the relations that exist, or that might exist, between these factors and the oestrogen-inducible trefoil factor TFF1. (C) 2004 Elsevier Ireland Ltd. All rights reserved.