PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis.
PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis.
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DOI：
10.1155/2012/843085
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发表时间：
2012
影响因子：
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通讯作者：
Matsuda S
中科院分区：
文献类型：
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作者：
Okumura N;Yoshida H;Kitagishi Y;Murakami M;Nishimura Y;Matsuda S
PI 3 K/AKT/PTEN信号通路在血管内皮生长因子介导的血管生成调控中起重要作用，在包括白血病在内的多种肿瘤中发挥重要作用。在白血病患者以及白血病细胞系中，信号通路被激活，同时PTEN基因表达降低。该信号通路调节血管生成的机制仍有待进一步阐明。然而，由于血管生成是恶性细胞生长的关键过程，它已成为抗白血病药物治疗的一个有吸引力的靶点。本文就PI 3 K/AKT/PTEN信号通路在血管生成调控中的作用及机制进行综述。
PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis.