Medetomidine Suppresses Cardiac and Gastric Sympathetic Nerve Activities but Selectively Activates Cardiac Vagus Nerve
Medetomidine Suppresses Cardiac and Gastric Sympathetic Nerve Activities but Selectively Activates Cardiac Vagus Nerve
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DOI：
10.1253/circj.cj-13-1456
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发表时间：
2014-06-01
影响因子：
3.3
通讯作者：
Sugimachi, Masaru
中科院分区：
文献类型：
--
作者：
Shimizu, Shuji;Akiyama, Tsuyoshi;Sugimachi, Masaru
背景：为了确定一种可以选择性激活心脏迷走神经的药物，用于治疗心力衰竭的迷走神经激活疗法，研究了美托咪定对心脏和胃自主神经活动的影响。方法和结果：在麻醉的兔子中，将微透析探针植入右心房和胃壁。通过高效液相色谱法测量透析液乙酰胆碱（ACh）和去甲肾上腺素（NE）浓度。首先，检查了100μg/kg静脉注射美托咪定对迷走神经ACh和交感神经NE释放的影响。美托咪定显着增加心脏 ACh 释放（4.7 +/- 1.1 至 7.8 +/- 0.9 nmol/L，P
Background: To identify a pharmacological agent that can selectively activate cardiac vagus nerve for potential use in vagal activation therapy against heart failure, the effects of medetomidine on autonomic nerve activities in both the heart and stomach were examined.Methods and Results: In anesthetized rabbits, microdialysis probes were implanted into both the right atrial and gastric walls. Dialysate acetylcholine (ACh) and norepinephrine (NE) concentrations were measured by high-performance liquid chromatography. First, the effects of 100 mu g/kg of intravenous medetomidine on vagal ACh and sympathetic NE releases were examined. Medetomidine significantly increased cardiac ACh release (4.7 +/- 1.1 to 7.8 +/- 0.9 nmol/L, P