EPIDEMIOLOGY OF CYTOMEGALO-VIRUS INFECTIONS IN YOUNG-CHILDREN - DAY-CARE VS HOME CARE
EPIDEMIOLOGY OF CYTOMEGALO-VIRUS INFECTIONS IN YOUNG-CHILDREN - DAY-CARE VS HOME CARE
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DOI：
10.1097/00006454-198503000-00008
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
PASS, RF
中科院分区：
文献类型：
--
作者：
HUTTO, C;RICKS, R;PASS, RF
将三个日托中心儿童的巨细胞病毒感染率与一组来自相似社会经济背景的家庭护理儿童的感染率进行了比较。日托中心1、2和3的病毒排泄率分别为41%（68人中的28人）、26%（58人中的15人）和55%（62人中的34人），日托中心所有儿童的合并感染率为41%（188人中的77人）。相比之下，15%（10/66）的家庭护理儿童巨细胞病毒血清学阳性，25例中只有2例（8%）脱落病毒（P< 0.001）。虽然家庭护理组的年龄中位数略低，但两组儿童在性别、种族、母乳喂养和父母年龄及教育背景方面相似。日托儿童和家庭护理儿童之间唯一的其他显著差异是他们每周接受近40小时的护理。各中心内各年龄组的感染率也各不相同，各中心内25至36个月的儿童感染率最高。幼儿日托可能与巨细胞病毒感染率高有关。导致感染率高于预期的传播机制仍有待确定。
Infection rates with cytomegalovirus among children in three day care centers were compared to that found in a group of children cared for in the home who were from a similar socio-economic background. Rates of viral excretion for Day Care Centers 1, 2 and 3 were 41%(28 of 68), 26%(15 of 58) and 55%(34 of 62), respectively, with a combined rate of infection for all children in day care of 41%(77 of 188). In contrast 15%(10 of 66) of children in home care were seropositive to cytomegalovirus, and only 2 of 25 (8%) were shedding virus (P< 0.001). Although the median age of the group in home care was slightly lower, the two groups of children were similar in sex, race, breast-feeding and parental ages and educational background. The only other notable difference between the children in day care and those in home care was the cavironment in which they received care for almost 40 hours every week. Rates of infection varied also among the age groups within each center, with the highest rate within each center occurring in children 25 to 36 months old. Day care for young children is likely to be associated with high rates of infection with cytomegalovirus. The mechanisms of transmission that are responsible for these higher than expected rates of infection remain to be defined.