Drug delivery via aerosol systems: concept of "aerosol inhaled".
Drug delivery via aerosol systems: concept of "aerosol inhaled".
复制标题
通过气雾剂系统输送药物：“吸入气雾剂”的概念。
DOI：
10.1089/jam.1991.4.229
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Smaldone,GC
中科院分区：
文献类型：
--
作者：
Smaldone,GC
吸入的气雾剂质量主要取决于患者的呼吸模式和气雾剂输送系统。一旦吸入，沉积受与气溶胶的性质和患者的个体特征（例如，粒度分布、气道几何形状和停留时间）。本文将集中在实际生产和交付的临床气雾剂喷射雾化器和评估的变化，气雾剂输送。由于从第一原理预测雾化器功能的实际困难，因此主张直接测量每种临床情况的雾化器功能。应避免使用“雾化器输出”、“效率”等术语。提出了以下定义：“吸入的气雾剂”表示在规定的呼吸模式和时间段内由给定的雾化器实际递送的药物量。“吸入气雾剂”的概念允许直接比较由不同雾化器系统递送的药物量和调整给定治疗剂的剂量。如果仔细注意实验室条件和实际使用之间的关系，包括颗粒分布和放射性标记在估计雾化药物量时的准确性，则可以在实验室中进行气雾剂系统的台架试验和“吸入气雾剂”的测量。
The mass of aerosol inhaled is primarily a function of the patient's breathing pattern and the aerosol delivery system. Once inhaled, deposition is governed by factors related to the properties of the aerosol and the individual characteristics of the patient (e.g., particle size distribution, airway geometry, and residence time). This paper will center upon the actual generation and delivery of clinical aerosols by jet nebulizers and assess variability in aerosol delivery. Because of the practical difficulties in predicting nebulizer function from first principles, it will be advocated that nebulizer function be directly measured for each clinical situation. Terms like "nebulizer output", "efficiency", etc. are to be avoided. The following definition is proposed: "aerosol inhaled" represents that quantity of drug actually delivered by a given nebulizer for a defined breathing pattern and period of time. The concept of "aerosol inhaled" allows a direct comparison of the quantity of drug delivered by different nebulizer systems and adjustment of dose of a given therapeutic agent. Bench testing of aerosol systems and measurement of "aerosol inhaled" can be made in the laboratory if careful attention is paid to the relationship between laboratory conditions and actual use, including the particle distribution and the accuracy of a radiolabel in estimating the quantity of drug nebulized.