Health-related quality of life after salvage high-intensity focused ultrasound (HIFU) treatment for locally radiorecurrent prostate cancer
Health-related quality of life after salvage high-intensity focused ultrasound (HIFU) treatment for locally radiorecurrent prostate cancer
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DOI：
10.1111/j.1442-2042.2011.02815.x
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发表时间：
2011-09-01
影响因子：
2.6
通讯作者：
Karlsen, Steinar Johan
中科院分区：
文献类型：
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作者：
Berge, Viktor;Baco, Eduard;Karlsen, Steinar Johan
目的：评价高强度聚焦超声(HIFU)挽救治疗局部放射性复发性前列腺癌(PCa)后患者的健康相关生活质量(HRQOL)。所有患者在基线和随访时都接受了加州大学洛杉矶分校前列腺癌指数(UCLA-PCI)问卷调查。得分从0(最差)到100(最好)不等。结果：57例(93%)患者在基线时有可评估的数据，而治疗后46例(75%)。从HIFU治疗到问卷回复的平均时间为17.5个月(6-29个月)。平均尿功能评分由治疗前的79.7+/-12.1降至治疗后的67.4+/-17.8(P<；0.001)。性功能评分由治疗前的32.1+/-24.1降至治疗后的17.2+/-17.0(P<；0.001)。对肠功能无明显影响。患者的生理HRQOL均分明显降低，而精神HRQOL均分无明显变化。结论：经平均17.5个月的随访，HIFU治疗局部复发性PCa可显著降低患者的性功能和尿量。
Objective: To evaluate health-related quality of life (HRQOL) after salvage high-intensity focused ultrasound (HIFU) for locally radiorecurrent prostate cancer (PCa).Methods: Since June 2006 we have treated 61 patients consecutively by salvage HIFU. All patients were offered the University of California, Los Angeles Prostate Cancer Index (UCLA-PCI) questionnaire at baseline and at follow-up. Scores ranged from 0 (worst) to 100 (best). Clinically significant changes were defined as a minimum difference of 10 points between the baseline score and the score at follow-up.Results: Fifty-seven patients (93%) had evaluable data at baseline, compared with 46 (75%) after treatment. The mean time lapse between HIFU treatment and questionnaire response was 17.5 months (range 6-29 months). The mean score for urinary function decreased from 79.7 +/- 12.1 prior to HIFU to 67.4 +/- 17.8 after HIFU (P < 0.001). The mean score for sexual function decreased from 32.1 +/- 24.1 prior to HIFU to 17.2 +/- 17.0 after HIFU (P < 0.001). There were no significant effects on bowel function. There was a significant reduction in the mean score for Physical HRQOL, but the mean score for Mental HRQOL was did not change significantly.Conclusion: Treatment of localized radiorecurrent PCa by salvage HIFU is associated with clinically significant reductions in urinary and sexual function domains after a mean follow-up of 17.5 months.