Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity
Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity
复制标题
肿瘤来源的可溶性 MICA 阻碍 NKG2D 通路以抑制 NK 细胞毒性。
DOI：
10.14336/ad.2019.1017
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发表时间：
2020-02-01
影响因子：
7.4
通讯作者：
Zou, Yizhou
中科院分区：
文献类型：
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作者：
Luo, Qizhi;Luo, Weiguang;Zou, Yizhou
自然杀伤组2D（NKG 2D）受体及其配体在免疫监视中起重要作用。在这项研究中，我们观察到174例肝细胞癌（HCC）患者的平均血清可溶性云母（sMICA）浓度显著高于80例健康受试者（602.17 ± 338.15 vs. 72.26 ± 87.88 pg/ml，t = 3.107，P 0.002）。44例原发性肝癌患者术前血清sMICA水平高于400 pWml，手术切除后血清sMICA水平明显下降（P
The natural killer group 2D (NKG2D) receptor and its ligands play important roles in immune surveillance. In this study, we observed that the average serum soluble MICA (sMICA) concentration of 174 hepatocellular carcinoma (HCC) patients was significantly higher than that in 80 healthy subjects (602.17 +/- 338.15 vs. 72.26 +/- 87.88 pg/ml, t = 3.107, P.002). The levels of serum sMICA in 44 HCC patients with initial levels above 400 pWml declined significantly after surgical removal of the fiver cancer tissue (P