Cell Biology Approaches to Studying Prion Diseases.
Cell Biology Approaches to Studying Prion Diseases.
复制标题
研究朊病毒疾病的细胞生物学方法。
DOI：
10.1007/978-1-4939-7244-9_7
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Priola,SuzetteA
中科院分区：
文献类型：
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作者：
Priola,SuzetteA
During the course of prion infection, the normally soluble and protease-sensitive mammalian prion protein (PrPC) is refolded into an insoluble, partially protease-resistant, and infectious form called PrPSc. The conformational conversion of PrPCto PrPScis a critical event during prion infection and is essential for the production of prion infectivity. This chapter briefly summarizes the ways in which cell biological approaches have enhanced our understanding of how PrP contributes to different aspects of prion pathogenesis.
