Functional Brain Networks and Cognitive Deficits in Parkinson's Disease
Functional Brain Networks and Cognitive Deficits in Parkinson's Disease
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DOI：
10.1002/hbm.22499
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发表时间：
2014-09-01
影响因子：
4.8
通讯作者：
Junque, Carme
中科院分区：
文献类型：
--
作者：
Baggio, Hugo-Cesar;Sala-Llonch, Roser;Junque, Carme
通过静息状态功能磁共振成像(FMRI)获得的功能网络的图论分析最近被证明是一种有用的方法来研究不同疾病认知障碍的基础。我们使用这项技术来研究帕金森氏病(PD)的认知缺陷是否与全球和局部网络测量的变化有关。36例健康对照(HC)和66例年龄、性别和教育程度匹配的PD患者被分为轻度认知损害(MCI)和非轻度认知损害(MCI)，根据PD中三个主要影响认知领域的表现：注意/执行、视觉空间/视觉操作(VS/VP)和陈述性记忆。静息状态功能磁共振成像和图论分析用于评估网络测量。我们发现，MCI患者的连接性降低，主要影响远程连接，以及局部互联性增加，表现为更高的集群性、小世界和模块化衡量标准。后一项指标也倾向于与VS/VP和记忆功能的认知表现负相关。中枢结构也进行了重组：在MCI PD患者中，正常中枢表现为中心性和程度降低。我们的研究表明，存在认知障碍的帕金森病患者大脑网络的拓扑属性发生了变化。我们的发现提供了关于帕金森病认知损害的功能基础的新数据，这可能被证明是一个有价值的预后标记物。(C)2014年威利期刊公司。
Graph-theoretical analyses of functional networks obtained with resting-state functional magnetic resonance imaging (fMRI) have recently proven to be a useful approach for the study of the substrates underlying cognitive deficits in different diseases. We used this technique to investigate whether cognitive deficits in Parkinson's disease (PD) are associated with changes in global and local network measures. Thirty-six healthy controls (HC) and 66 PD patients matched for age, sex, and education were classified as having mild cognitive impairment (MCI) or not based on performance in the three mainly affected cognitive domains in PD: attention/executive, visuospatial/visuoperceptual (VS/VP), and declarative memory. Resting-state fMRI and graph theory analyses were used to evaluate network measures. We have found that patients with MCI had connectivity reductions predominantly affecting long-range connections as well as increased local interconnectedness manifested as higher measures of clustering, small-worldness, and modularity. The latter measures also tended to correlate negatively with cognitive performance in VS/VP and memory functions. Hub structure was also reorganized: normal hubs displayed reduced centrality and degree in MCI PD patients. Our study indicates that the topological properties of brain networks are changed in PD patients with cognitive deficits. Our findings provide novel data regarding the functional substrate of cognitive impairment in PD, which may prove to have value as a prognostic marker. (C) 2014 Wiley Periodicals, Inc.