Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery
Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery
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DOI：
10.1038/ejcn.2009.127
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发表时间：
2010-02-01
影响因子：
4.7
通讯作者：
Black, R. E.
中科院分区：
文献类型：
--
作者：
Chang, S.;El Arifeen, S.;Black, R. E.
背景/目的：许多儿童的饮食同时缺乏铁和锌，但有一些证据表明，当它们同时补充时，会产生负面作用。最佳的给药方法将使这两种营养素的临床益处最大化。研究设计：随机、双盲、安慰剂对照的因素社区试验。结果：单独补充铁和锌会增加腹泻，但单独或联合添加锌可以减轻这些有害影响。对于铁的结果，锌和铁的组合与单独使用铁一样有效。所有的补充剂都被呕吐了
Background/Objectives: Many children have diets deficient in both iron and zinc, but there has been some evidence of negative interactions when they are supplemented together. The optimal delivery approach would maximize clinical benefits of both nutrients. We studied the effectiveness of different iron and zinc supplement delivery approaches to improve diarrhea and anemia in a rural Bangladesh population.Study Design: Randomized, double blind, placebo-controlled factorial community trial.Results: Iron supplementation alone increased diarrhea, but adding zinc, separately or together, attenuated these harmful effects. Combined zinc and iron was as effective as iron alone for iron outcomes. All supplements were vomited