Vascular endothelial growth factor receptor 1 expression in pelvic lymph nodes predicts the risk of cancer progression after radical prostatectomy
Vascular endothelial growth factor receptor 1 expression in pelvic lymph nodes predicts the risk of cancer progression after radical prostatectomy
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DOI：
10.1111/j.1349-7006.2009.01146.x
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发表时间：
2009-06-01
期刊：
影响因子：
5.7
通讯作者：
Nonomura, Norio
中科院分区：
文献类型：
--
作者：
Fujita, Kazutoshi;Nakayama, Masashi;Nonomura, Norio
最近的研究表明，血管内皮生长因子受体(VEGFR)1阳性的造血祖细胞在肿瘤细胞到来之前形成簇，可能预示着未来转移疾病的发生。本研究的目的是阐明盆腔淋巴结中VEGFR1的表达是否可以预测前列腺癌根治术后进展的风险。应用免疫组织化学方法检测95例前列腺癌根治术患者盆腔淋巴结中VEGFR1的表达。一簇VEGFR1阳性细胞被认为是阳性。采用单因素生存分析和多因素COX比例风险回归分析分析VEGFR1在盆腔淋巴结中的表达和前列腺癌根治术后的生化复发情况。在79例淋巴结阴性的患者中，37例(46.8%)的盆腔淋巴结中有VEGFR1阳性细胞，而16例淋巴结转移阳性的患者中，有16例(100%)有VEGFR1阳性细胞。肿瘤的病理分期与血管内皮细胞生长因子受体表达呈显著正相关(P=0.002)。单因素分析显示，病理分期>；=PT3和VEGFR1在盆腔淋巴结中的表达均与前列腺癌根治术后生化复发显著相关。多因素分析显示，VEGFR1mRNA表达是前列腺癌根治术后生化复发的独立预测因子(Risk Ratio=5.715，P=0.010)，术前前列腺特异性抗原(PSA)水平为10 ng/mL。尽管还需要更大规模的验证研究，但我们的结果表明，盆腔淋巴结中VEGFR1的表达可以预测前列腺癌根治术后生化PSA复发的风险。(癌症科学2009；100：1047-1050)。
Recent studies suggest that vascular endothelial growth factor receptor (VEGFR) 1-positive hematopoietic progenitor cells precede the arrival of tumor cells and form clusters that may portend sites of future metastatic disease. The aim of the present study was to clarify whether VEGFR1 expression in pelvic lymph nodes predicts the risk of prostate cancer progression after radical prostatectomy. VEGFR1 expression in pelvic lymph nodes was examined by immunohistochemistry in 95 patients who underwent radical prostatectomy for prostate cancer. A cluster of VEGFR1-positive cells was considered positive. Expression of VEGFR1 in pelvic lymph nodes and biochemical recurrence after radical prostatectomy were examined by univariate survival analysis and multivariate Cox proportional hazards regression analysis. Thirty-seven of 79 lymph node-negative patients (46.8%) were found to have VEGFR1-positive cells in their pelvic lymph nodes, whereas 16 of 16 lymph node metastasis-positive patients (100%) had VEGFR1 clusters. There was a significant correlation between pathological stage and VEGFR1 staining (P = 0.002). Univariate analysis showed that pathological stage >= pT3 and VEGFR1 expression in pelvic lymph nodes were each significantly associated with biochemical recurrence after radical prostatectomy. Multivariate analysis showed VEGFR1 expression to be an independent predictor of biochemical recurrence after radical prostatectomy (risk ratio = 5.715, P = 0.010), as was preoperative prostate-specific antigen (PSA) level >= 10 ng/mL. Although larger validation studies are required, our results suggest that VEGFR1 expression in pelvic lymph nodes predicts the risk of biochemical PSA recurrence after radical prostatectomy. (Cancer Sci 2009; 100: 1047-1050).