Emotion dysregulation in adults with ADHD: The role of cognitive reappraisal and expressive suppression
Emotion dysregulation in adults with ADHD: The role of cognitive reappraisal and expressive suppression
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成人多动症患者的情绪失调：认知重评和表达抑制的作用
DOI：
10.1016/j.jad.2022.09.058
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发表时间：
2022
影响因子：
6.6
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Liu QR;Chen W;Preece DA;Xu DF;Li HM;Liu NN;Fu GH;Wang YF;Qian QJ;Gross JJ;Liu L
研究背景情绪调节障碍（艾德）是注意缺陷多动障碍（ADHD）的常见临床特征。本研究探讨了认知再评价（CR）和表达抑制（ES）在成人ADHD中的作用。此外，静息态功能磁共振成像（rs-fMRI）数据进行了分析，以确定CR/ES-ED relationships.MethodsA共309成人ADHD和163名健康对照招募神经基板。艾德使用执行功能行为评定量表成人版中的“情绪控制”（EC）分量表进行评估。采用情绪调节问卷测量CR和ES。与杏仁核作为感兴趣的区域的功能连通性（FC）进行了分析，在一个子样本中，探讨其与CR，ES和EC，respectively.ResultsHigher EC scores（表示较少的情绪控制），以及较低的CR和更高的ES利用率检测在成人ADHD与健康对照组相比。ADHD成人的CR、ES与EC均呈负相关。中介分析检测到ADHD诊断通过CR对EC的潜在影响。此外，一个独特的显着的中介作用被发现之间的ES-相关的FC的右杏仁核-前额叶皮层和艾德的表达在成人多动症，证实了'↑ES → ↓FCs[amygR-PFC]→↓EC'的关系。而更频繁地使用ES可能在情绪调节中发挥独特的补偿作用。
BackgroundEmotion dysregulation (ED) is a common clinical feature of attention-deficit/hyperactivity disorder (ADHD). The present study examined the role of cognitive reappraisal (CR) and expressive suppression (ES) in adults with ADHD. In addition, resting-state fMRI (rs-fMRI) data were analyzed to identify neural substrates of CR/ES-ED relationships.MethodsA total of 309 adults with ADHD and 163 healthy controls were recruited. ED was assessed using the ‘emotional control’ (EC) subscale from Behavior Rating Inventory of Executive Function-Adult Version. The Emotion Regulation Questionnaire was used to measure CR and ES. The functional connectivities (FCs) with the amygdala as Region of Interest, were analyzed in a subsample to explore their association with CR, ES and EC, respectively.ResultsHigher EC scores (indicative of lesser emotional control), as well as lower CR and higher ES utilization were detected in adults with ADHD compared with healthy controls. CR and ES were both negatively correlated with EC in adults with ADHD. Mediation analysis detected a potential effect of ADHD diagnosis on EC via CR. In addition, a unique significant mediation effect was found between ES-related FC of the right amygdala-prefrontal cortex and ED expression in adults with ADHD, confirming the ‘↑ES → ↓FCs[amygR-PFC]→↓EC’ relationship.LimitationsOnly self-reported scales and rs-fMRI data were included in these analyses.ConclusionsOur findings provide preliminary evidence that in adults with ADHD, less frequent use of CR accounts for ED expression, while more frequent use of ES may play a unique compensatory role in emotion regulation.