Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng
Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng
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三七蒸根中的少量脱氢裂解达玛烷型皂苷
DOI：
10.1016/j.fitote.2015.03.014
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发表时间：
2015-06-01
期刊：
影响因子：
3.4
通讯作者：
Zhang, Ying-Jun
中科院分区：
文献类型：
--
作者：
Gu, Cheng-Zhen;Lv, Jun-Jiang;Zhang, Ying-Jun
从三七（Panax notoginseng）的蒸制根中分离得到9个新的少量脱氢和裂解的达玛烷型三萜皂苷，即三七皂苷ST 6-ST 14（1-9）。其中5-7和21-22为原人参二醇型皂苷，其余18个化合物为原人参三醇型皂苷，其中1-4、8-20和23为原人参三醇型皂苷。它们的结构经MS、1D和2D NMR谱和酸水解鉴定。新皂苷1和2的C-25位为酮基，3-5的C-23位为醛基。已知的皂苷12、16和18在10 μ M浓度下显示出促进NGF介导的PC 12细胞突起生长的潜力，而20显示出乙酰胆碱酯酶抑制活性，IC 50值为13.97 μ M。(C)2015 Elsevier B. V.版权所有。
Nine new minor dehydrogenated and cleavaged dammarane-type triterpenoid saponins, namely notoginsenosides ST6-ST14 (1-9) were isolated from the steamed roots of Panax notoginseng, together with 14 known ones. Among them, 5-7 and 21-22 were protopanaxadiol type and the left 18 compounds, including 1-4, 8-20, and 23 were protopanaxatriol type saponins. Their structures were identified by extensive analysis of MS, 1D and 2D NMR spectra, and acidic hydrolysis. Resulted from the side chain cleavage, the new saponins 1 and 2 featured in a ketone group at C-25, and 3-5 had an aldehyde unit at C-23. The known saponins 12,16 and 18 displayed the enhancing potential of neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 mu M, while 20 exhibited acetyl cholinesterase inhibitory activity, with IC50 value of 13.97 mu M. (C) 2015 Elsevier B.V. All rights reserved.