IFN-gamma mediated pathways in patients with fatigue and chronic active Epstein Barr virus-infection
IFN-gamma mediated pathways in patients with fatigue and chronic active Epstein Barr virus-infection
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DOI：
10.1016/j.jad.2007.09.005
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发表时间：
2008-05-01
影响因子：
6.6
通讯作者：
Weiss, Guenter
中科院分区：
文献类型：
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作者：
Bellmann-Weiler, Rosa;Schroecksnadel, Katharina;Weiss, Guenter
背景：慢性活动性 Epstein Barr 病毒 (EBV) 感染的特征是单核细胞增多症样症状，包括疲劳、淋巴结肿大和/或肝脾肿大以及持续 EBV 复制的血清学证据。干扰素-γ (IFN-γ) 会在靶细胞中触发多种抗病毒机制，包括诱导吲哚胺-2,3-双加氧酶 (IDO)，将必需氨基酸色氨酸降解为犬尿氨酸。由于色氨酸是神经递质 5-羟色胺（血清素）的前体，IDO 造成的色氨酸消耗会导致慢性免疫激活患者的情绪紊乱。 方法：本研究调查了 20 名慢性活动性 EBV 感染患者和 10 名年龄匹配的健康对照患者的色氨酸代谢，并对其进行了 4 至 8 个月的随访。通过针对 EBV 早期抗原 (EA) 和病毒衣壳抗原 (VCA) 的循环抗体的存在，证实临床怀疑慢性活动性 EBV 感染。 结果：可检测到 EBV-DNA 的患者血清新蝶呤水平较高 (p
Background: Chronic active Epstein Barr virus (EBV)-infection is characterized by mononucleosis like symptoms including fatigue, lymphadenopathy and/or hepatosplenomegaly and serologic evidence for ongoing EBV replication. Interferon-gamma (IFN-gamma) triggers several antiviral mechanisms in target cells including the induction of indoleamine-2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan to kynurenine. Because tryptophan is a precursor of the neurotransmitter 5-hydroxytryptamine (serotonin), tryptophan depletion by IDO can cause mood disturbances in patients with chronic immune activation.Methods: This study investigated the tryptophan metabolism in 20 patients with chronic active EBV-infection, who were followed up for 4 to 8 months and in 10 healthy age-matched controls. The clinical suspicion of chronic active EBV infection was verified by the presence of circulating antibodies against EBV early antigen (EA) and virus capsid antigen (VCA).Results: Patients with detectable EBV-DNA had higher serum neopterin (p