Trilayered polymeric micelle : a newly-developed macromolecular assembly that can incorporate hydrophilic compounds
Trilayered polymeric micelle : a newly-developed macromolecular assembly that can incorporate hydrophilic compounds
复制标题
三层聚合物胶束：一种新开发的大分子组装体，可以结合亲水性化合物
DOI：
10.1016/j.colsurfb.2010.03.047
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Y. and Y. Murakami
中科院分区：
文献类型：
--
作者：
Uchida;Y. and Y. Murakami
我们开发了一种新的大分子组装体，一种三层聚合物胶束，它可以包裹亲水性化合物。通过对成相有机溶剂的组成、乳化稳定剂的浓度等因素的考察，确定了制备稳定的w/o乳液的最佳条件。然后，在制备稳定的w/o乳液的最佳条件下，制备了三层聚合物胶束。DLS、GPC、1H NMR和荧光显微镜的结果表明，成功地制备了三层聚合物胶束。还阐明了胶束可以将模型亲水性化合物FITC-葡聚糖包封到胶束的核心中。胶束可以预期通过可能优化形成胶束壳层的PLA链段的缠结来有效地掺入/释放化合物。这些特征强烈表明胶束未来可以有多种应用，特别是在医学领域。
We developed a newly developed macromolecular assembly, a trilayered polymeric micelle, which can encapsulate hydrophilic compounds. The optimal condition for preparing a stable w/o emulsion was determined by the evaluation of several factors such as the composition of phase-forming organic solvents and the concentration of an emulsion stabilizer. Then, the trilayered polymeric micelle was prepared under the optimal condition for preparing the stable w/o emulsion. The results of DLS, GPC,1H NMR, and fluorescence microscopy suggested that the trilayered polymeric micelle was successfully prepared. It was also clarified that the micelle can encapsulate the model hydrophilic compound, FITC-dextran, into the core of the micelle. The micelle can be expected to incorporate/release compounds effectively by means of the possible optimization of the entanglement of PLA segments forming the shell layer of the micelle. These features strongly suggest that the micelle can have a variety of future applications, especially in medical fields.